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Carbohydrate and electrolyte injection and preparation method thereof

An electrolyte injection and mixed sugar technology, applied in the field of medicine, can solve the problems of unstable mixed sugar electrolyte injection, precipitation of white substances, low dissolution temperature, etc., and achieve the effects of avoiding yellowing of samples, small content changes, and low cost.

Active Publication Date: 2013-09-25
JIANGSU CHIA TAI FENGHAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low dissolution temperature of this method, especially when the pH is high, the sample will turn yellow after sterilization, and a small amount of white matter will precipitate out, and the prepared mixed sugar electrolyte injection is unstable.

Method used

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  • Carbohydrate and electrolyte injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mixed sugar electrolyte injection, the prescription is as follows:

[0025] 30 parts of glucose, 15 parts of fructose, 7.5 parts of xylitol, 0.73 parts of sodium chloride, 0.41 parts of sodium acetate, 0.185 parts of calcium chloride, 0.255 parts of magnesium chloride, 0.87 parts of dipotassium hydrogen phosphate, 0.0007 parts of zinc sulfate, bisulfite 0.21 parts of sodium, 250 parts of water for injection; pH is 5.1.

[0026] Weigh glucose, fructose, xylitol, sodium chloride, sodium acetate, calcium chloride, magnesium chloride, dipotassium hydrogen phosphate, zinc sulfate, sodium bisulfite according to the above prescription amount, add 90% of the prepared amount and inject at 85°C With water, stir until completely dissolved. Add activated carbon for needles to the above solution, the volume ratio of the mass of the activated carbon to the mixed solution is 0.05g: 100ml, and stir continuously for 15 minutes under the heating condition of 55-65°C, filter the solution...

Embodiment 2

[0028] Mixed sugar electrolyte injection, the prescription is as follows:

[0029] 30 parts of glucose, 15 parts of fructose, 7.5 parts of xylitol, 0.73 parts of sodium chloride, 0.41 parts of sodium acetate, 0.185 parts of calcium chloride, 0.255 parts of magnesium chloride, 0.87 parts of dipotassium hydrogen phosphate, 0.0007 parts of zinc sulfate, bisulfite 0.21 parts of sodium, 250 parts of water for injection; pH is 5.5.

[0030] Weigh glucose, fructose, xylitol, sodium chloride, sodium acetate, calcium chloride, magnesium chloride, dipotassium hydrogen phosphate, zinc sulfate, sodium bisulfite according to the above prescription amount, add 90% of the prepared amount and inject at 75°C With water, stir until completely dissolved. Add activated carbon for needles to the above solution, the volume ratio of the mass of the activated carbon to the mixed solution is 0.05g: 100ml, and stir continuously for 20 minutes under the heating condition of 55-65°C, filter the solution...

Embodiment 3

[0032] Mixed sugar electrolyte injection, the prescription is as follows:

[0033] 30 parts of glucose, 15 parts of fructose, 7.5 parts of xylitol, 0.73 parts of sodium chloride, 0.41 parts of sodium acetate, 0.185 parts of calcium chloride, 0.255 parts of magnesium chloride, 0.87 parts of dipotassium hydrogen phosphate, 0.0007 parts of zinc sulfate, bisulfite 0.21 parts of sodium, 250 parts of water for injection; pH is 5.3.

[0034] Weigh glucose, fructose, xylitol, sodium chloride, sodium acetate, calcium chloride, magnesium chloride, dipotassium hydrogen phosphate, zinc sulfate, sodium bisulfite according to the above prescription amount, add 90% of the prepared amount and inject at 80°C With water, stir until completely dissolved. Add activated carbon for needles to the above solution, the volume ratio of the mass of activated carbon to the mixed solution is 0.05g: 100ml, stir continuously for 10 minutes under the heating condition of 55-65°C, filter the solution while i...

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Abstract

The invention provides a carbohydrate and electrolyte injection which comprises the following components by weight part: 30 parts of glucose, 15 parts of fructose, 7.5 parts of xylitol, 0.73 part of sodium chloride, 0.41 part of sodium acetate, 0.185 part of calcium chloride, 0.255 part of magnesium chloride, 0.87 part of dipotassium phosphate, 0.0007 part of zinc sulfate, 0.21 part of sodium bisulfite and 250 parts of water for injection; and the PH value is 5.1-5.5. The injection is low in cost and wide in applicable range. The invention also provides a preparation method of the carbohydrate and electrolyte injection. The preparation method comprises the steps of dissolving carbohydrate and electrolyte (as raw and auxiliary materials), absorbing, decarbonizing, adjusting the pH, and sterilizing to obtain the carbohydrate and electrolyte injection. According to the preparation method, the process is simple, the method is suitable for industrial production, the problems that samples turn yellow after the sterilization, and white substances are separated out can be avoided by increasing the dissolving temperature to be 75 DEG C-85 DEG C and adjusting the pH of the solution, so that the carbohydrate and electrolyte injection is stable.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a mixed sugar electrolyte injection and a preparation method thereof. Background technique [0002] Under the invasion of various germs and during the operation period, the human body not only needs to replenish water and electrolytes, but also needs to supplement the nutritional heat source mainly sugar, so many nutritional infusion preparations have been developed. Due to the wide variety of sources of glucose and the low price, glucose-electrolyte injections currently used clinically in China are mainly glucose-sodium chloride injections. However, it is very monotonous in terms of energy supplementation and electrolyte supplementation, which cannot meet clinical needs. At the same time, for diabetics, due to the abnormal glucose tolerance of diabetics, the metabolic load after glucose injection is heavy, and glucose cannot be effectively used. In addition, using only glucose...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/42A61K9/08A61P3/12A61P3/02A61K33/30A61K31/7004A61K31/047A61K33/06A61K33/14A61K31/19A61K33/00
Inventor 董静朱永强朱勇
Owner JIANGSU CHIA TAI FENGHAI PHARMA
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