Method for controlling air quantity during production of 1,3-propylene glycol

Abstract

The invention discloses a method for controlling air quantity during the production of 1,3-propylene glycol, which is operated according to the following process steps of: (1) introducing the air quantity of 500 l / hour for about 8 hours of a primary fermentation stage to ensure thalli to be fast grown and achieve a higher bacterial concentration level of OD650=8; (2) then decreasing the air quantity to 200-300 l / hour, wherein the successive high yield of 3-hydroxy propanal is stimulated at the small air quantity time of 12 hours; and (3) increasing the air quantity again to 500 l / hour, wherein fermentation is completed at the large air quantity time of 16 hours. In the invention, the air quantity is duly regulated by adopting appropriate frequency according to different characteristics of stages in a fermentation process, thereby most effectively achieving the fermentation effect of much 3-hydroxy propanal and little lactic acid; convenience for separation and lower cost are achieved; and the yield of the 1,3-propylene glycol is obviously increased.

Description

technical field [0001] The invention belongs to the technical field of biological fermentation, and in particular relates to a method for controlling air volume in 1,3-propanediol production. Background technique [0002] The process route for producing 1,3-propanediol by biological fermentation has two branches, one is to generate 3-hydroxypropionaldehyde from glycerol, and then produce the target product 1,3-propanediol; the other is to start from glycerol and pass through the tricarboxylic acid cycle, Complete the basic metabolism of the bacteria itself, and at the same time generate by-products such as lactic acid, acetic acid, butanediol. [0003] In this process, low air volume can promote the production of 3-hydroxypropionaldehyde, thereby ensuring the acquisition of 1,3-propanediol; at the same time, low air volume leads to a large amount of by-product lactic acid, which not only consumes the reaction substrate glycerol, but also Increased the difficulty of separati...

AI Technical Summary

Problems solved by technology

Obviously, this compromise sacrifices some capacity

However, in the existing production process, the air volume is basically unchanged throughout the fermentation process, and the beneficial effect of the air volume on the entire fermentation has not been realized more effectively.

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