Application of fucoidan sulfate in preparation of drug for preventing and treating chronic obstructive pulmonary disease (COPD)

A chronic obstructive, fucoidan technology, applied in the direction of drug combination, respiratory diseases, etc., can solve problems such as the use of fucoidan sulfate, which has not been documented in the literature, achieve good preventive and therapeutic effects, enhance immune function, and have good safety Effect

Inactive Publication Date: 2012-11-07
吉林省辉南长龙生化药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is no literature showing the use of fucoidan sulfate in the prevention and treatment of chronic obstructive pulmonary disease

Method used

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  • Application of fucoidan sulfate in preparation of drug for preventing and treating chronic obstructive pulmonary disease (COPD)
  • Application of fucoidan sulfate in preparation of drug for preventing and treating chronic obstructive pulmonary disease (COPD)
  • Application of fucoidan sulfate in preparation of drug for preventing and treating chronic obstructive pulmonary disease (COPD)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: kelp ( Laminaria japonica ) Preparation of Fucoidan Sulfate and Fractional Components

[0025] (1) Remove silt from 5kg kelp, add 100L 0.1M hydrochloric acid and stir at room temperature to extract for 3 hours. Adjust the pH of the filtrate to 5-7, filter with diatomaceous earth, ultra-filter the filtrate, concentrate, add 4 times the volume of the concentrated solution in absolute ethanol for precipitation, wash the precipitate with absolute ethanol, and dry it in vacuum to obtain fucoidan sulfate FPS 602 g.

[0026](2) Dissolve the kelp fucoidan sulfate obtained above in water to make an aqueous solution with a concentration of 2.5%, load the sample to column chromatography with DEAE-Sepharose-CL-6B as the carrier, and use 0.5 mol / L NaCl, 1.0 mol / L NaCl and 2.0 mol / L NaCl solution linear gradient elution, each eluate was collected, dialyzed and freeze-dried respectively. Among them, 0.5 mol / L NaCl eluted to obtain fucoidan sulfate fraction fraction F...

experiment example 1

[0031] Experimental Example 1 Therapeutic effect of fucoidan sulfate on rats with chronic obstructive pulmonary disease

[0032] Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease with a large number of patients, a high mortality rate, and a heavy social and economic burden. It has become an important global public health problem. How to prevent the occurrence of COPD, stop or delay its development is a very important research topic at present. COPD is characterized by airflow limitation that is not fully reversible. Chronic inflammation of the airway and lung parenchyma is its characteristic change. Inflammation leads to repeated damage to the airway wall, resulting in remodeling of the tracheal structure and increased collagen content. and scar formation. In this experiment, the effect of fucoidan sulfate and its different components on airway inflammation and remodeling in COPD was studied through a rat model, and its therapeutic effect on COPD ...

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Abstract

The invention relates to a new application of fucoidan sulfate in preparation of drug for preventing and treating chronic obstructive pulmonary disease (COPD). The fucoidan sulfate has fucose content greater than 29% and sulfate group content greater than 30%; and is a polysaccharide sulfate extracted from Phaeophyta algae such as Zostera Marina L., Laminaria Japonica Aresch., Sargassum Phyllocystum, Surgassum Thunbergii, Sargassum Integerrimum, Sargassum Fusiforme (Harv.) Setchel, Sargassum naozhouense, Sargassum Muticum, Sargassum Pallidum, etc. Animal tests show that fucoidan sulfate has definite curative effects in preventing and treating COPD, and relieving development of COPD.

Description

technical field [0001] The present invention relates to a new use of fucoidan sulfate, that is, the use of fucoidan sulfate in the preparation of drugs for the prevention and treatment of chronic obstructive pulmonary disease. Background technique [0002] In the prior art, chronic obstructive pulmonary disease is called chronic obstructive pulmonary disease (COPD) for short, and it includes diseases such as chronic bronchitis (old chronic bronchitis) and emphysema. Its pathological feature is chronic obstruction of pulmonary airflow, which affects normal breathing and eventually leads to respiratory failure. Common symptoms are: recurrent coughing; wheezing, inability to breathe normally and panting. At present, there are about 40 million COPD patients in China, and 5 people die of COPD every minute, so it is called a quiet "killer". COPD is primarily caused by noxious particles or gases (most commonly from smoking) that trigger an abnormal inflammatory response in the lu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P11/00
Inventor 张全斌张弘
Owner 吉林省辉南长龙生化药业股份有限公司
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