External use ointment for promoting wound healing without scar pigment and preparation method of external use ointment

A technology of wound healing and topical ointment, which is applied in the direction of medical preparations containing active ingredients, ointment delivery, drug combination, etc., can solve problems that have not been seen yet, achieve no scar and pigmentation, protect the wound surface, and smooth the skin of the wound surface Effect

Inactive Publication Date: 2012-11-21
武汉东保科技开发有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, wound-type topical ointments sold in the pharmaceutical market mainly play anti-inflammatory and healing functions, and have not yet seen ones that can effectively eliminate scars and pigmentation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: the preparation of hydrophilic ointment base cream for external use

[0043] 1) Take commercially available raw materials: Centella asiatica extract 20g, aloe extract 20g, salvia miltiorrhiza extract 12g, knotweed extract 8g, dandelion extract 7g and Burnet extract 6g, mix well;

[0044] 2) Soak the mixture in ethanol with a concentration of 75% by mass, reflux and refine it at 70-80°C for 3 times, combine the filtrate each time, and perform conventional decolorization treatment;

[0045] 3) Concentrate the decolorizing solution into an extract, lower the temperature to 40-50°C, add 10g of pearl powder, 6g of bletilla striata powder and 2g of tea polyphenol powder, mix and stir to room temperature, then add 0.1g of peppermint oil, 0.3 of chlorhexidine g, continue to stir evenly to obtain a mother paste containing active ingredients;

[0046] 4) The hydrophilic ointment base contains 25% white petrolatum, 25% stearyl alcohol, 12% propylene glycol and 1.5% ...

Embodiment 2

[0047] Embodiment 2: the preparation of water-in-oil cream matrix topical ointment

[0048] 1) Take commercially available raw materials: 25g of centella asiatica extract, 22g of aloe extract, 8g of salvia miltiorrhiza extract, 10g of knotweed extract, 6g of dandelion extract and 8g of Burnet extract, and mix well;

[0049] 2) Soak the mixture in ethanol with a concentration of 95% by mass, reflux and refine it twice at 70-80°C, combine the filtrates each time, and perform conventional decolorization treatment;

[0050] 3) Concentrate the decolorization solution into an extract, lower the temperature to 40-50°C, add 15g of pearl hydrolyzate, 8g of bletilla striata powder and 1g of tea polyphenol powder, mix and stir to room temperature, then add 0.08g of peppermint oil and chlorhexidine 0.5g, continue to stir evenly to obtain a mother paste containing active ingredients;

[0051] 4) Water-in-oil cream base (W / O cream base) contains 10% glyceryl monostearate, 10% solid paraffi...

Embodiment 3

[0052] Embodiment 3: the preparation of emulsion base cream for external use

[0053] 1) Take commercially available raw materials: 15g of centella asiatica extract, 18g of aloe extract, 15g of salvia miltiorrhiza extract, 5g of knotweed extract, 5g of dandelion extract and 10g of Burnet extract, and mix well;

[0054] 2) Soak the mixture in ethanol with a concentration of 80% by mass, reflux at 70-80°C for three times, combine the filtrates each time, and perform conventional decolorization treatment;

[0055] 3) Concentrate the decolorizing solution into an extract, lower the temperature to 40-50°C, add 18g of pearl powder, 5g of bletilla striata powder and 1.5g of tea polyphenol powder, mix and stir to room temperature, then add 0.05g of peppermint oil and chlorhexidine 0.2g, continue to stir evenly to obtain a mother paste containing active ingredients;

[0056] 4) The emulsion base contains 1.5% stearic acid, 6% white petrolatum, 1.5% cetyl alcohol, 0.3% olive oil, 0.5% ...

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PUM

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Abstract

The invention relates to external use ointment for promoting wound healing without scar pigment and a preparation method of the external use ointment. The external use ointment belongs to ointment prepared from the following ingredients through being mixed in percentage by weight: 5 to 25 parts of centella extracts, 5 to 25 parts of aloe extracts, 5 to 20 parts of salviae miltiorrhizae extracts, 3 to 15 parts of polygonum cuspidatum extracts, 3 to 15 parts of dandelion extracts, 2 to 10 parts of garden burnet extracts, 5 to 20 parts of pearl powder or hydrolyzed pearl solution, 2 to 10 parts of bletilla powder, 0.5 to 3 parts of tea polyphenol powder and 700 to 950 parts of ointment base. The preparation method comprises the following steps that firstly, the extracts of centella, aloe, salviae miltiorrhizae, polygonum cuspidatum, dandelion and garden burnet are fully mixed, ethanol is used for fine extraction for 2 to 3 times, filter liquid is merged, decoloration and concentration are carried out to obtain extractum, and the temperature is lowered to 40 to 50 DEG C; then, the pearl powder or hydrolyzed pearl solution, the bletilla powder and the tea polyphenol powder are added and are mixed and stirred until the temperature is lowered to the room temperature; and finally, the mixture is fully and uniformly ground with the ointment base, and the external use ointment provided by the invention can be prepared. The external use ointment is suitable for surgical operations of burn wounds, empyrosis, beauty treatment and the like, and has the effects that the wound healing is accelerated, no scar or pigment is left, and the skin is smooth.

Description

technical field [0001] The invention relates to an external liniment prepared from Chinese medicinal materials, in particular to an external ointment for promoting wound healing without leaving scar pigment and a preparation method thereof. Background technique [0002] In daily life, everyone will inevitably have bumps and abrasions, and quite a few of them will leave scars and pigmentation during the wound recovery process. For large-scale trauma such as surgery, gynecological surgery, cosmetic plastic surgery, etc., it is easy to form scars and pigments on the wound healing site, causing troubles for many people, especially young people. Scar is a natural product in the process of human wound repair. When a large area of ​​epidermis is damaged or the skin is damaged and the dermis is involved, so that the epidermis at the damaged site cannot be regenerated, it will be replaced by dermal fibroblasts, collagen and proliferated blood vessels. Scars formed. Trauma, infectio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/06A61P17/02
Inventor 王务鼎胡荣大王滋红蔡麒文吴晶玲
Owner 武汉东保科技开发有限责任公司
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