Chinese magnoliavine fruit polysaccharide extract and preparation method and application thereof

A technology of polysaccharide extraction and Schisandra chinensis, which is applied in application, food preparation, food science, etc.

Inactive Publication Date: 2012-12-05
SHANGHAI HUATUO MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no published literature or patent report about the antiallergic activity of Schisandra polysaccharides

Method used

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  • Chinese magnoliavine fruit polysaccharide extract and preparation method and application thereof
  • Chinese magnoliavine fruit polysaccharide extract and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of Schisandra polysaccharide extract

[0032]Take 2 kg of schisandra medicinal material, grind it into the coarsest powder, add 80% ethanol with 8 times the weight of schisandra powder, and reflux extraction twice, each time for 2 hours, after the extraction is completed and cooled to room temperature, filter; Reflux extraction twice, each time for 2 hours, after the extraction is completed and cooled to room temperature, filter, combine the water extracts, and concentrate under reduced pressure to 0.4g of crude drug per ml; the concentrated solution is centrifuged, and the solution is further concentrated under reduced pressure to a relative density of 1.15 / 60°C, add 95% ethanol, measure with an alcohol hydrometer until the alcohol content is 80%, let it stand still, centrifuge to obtain a precipitate, wash the precipitate with 2 times the weight of absolute ethanol and acetone respectively, and obtain the crude polysaccharide extract 176 grams; ...

Embodiment 2

[0033] Example 2 Preparation of Schisandra polysaccharide extract

[0034] Take 2 kg of Schisandra medicinal material, crush it into coarse powder, add 80% ethanol which is 8 times the weight of Schisandra powder, and reflux extraction 3 times, each time for 1.5 hours, after the extraction is completed and cooled to room temperature, filter; Extract twice, each time for 2 hours, after the extraction is completed and cooled to room temperature, filter, combine the water extracts, concentrate under reduced pressure to contain 0.4g of crude drug per ml; centrifuge the concentrated solution, and further concentrate under reduced pressure to a relative density of 1.15 / 60 ℃, add 95% ethanol, measure with an alcohol hydrometer until the alcohol content is 85%, let stand, centrifuge to obtain a precipitate, and wash the precipitate with 2 times the weight of absolute ethanol and acetone respectively to obtain 180 grams of crude polysaccharide extract The polysaccharide extract crude p...

Embodiment 3

[0035] Example 3 Preparation of Schisandra polysaccharide extract

[0036] Take 4 kg of Schisandra medicinal material, grind it into the coarsest powder, add 65% ethanol 10 times the weight of Schisandra powder, reflux extraction for 3 hours, after the extraction is completed and cool to room temperature, filter; add 6 times the weight of water to the dregs, reflux extraction 3 times, Each time for 2 hours, after the extraction is completed and cooled to room temperature, filter, combine the water extracts, and concentrate under reduced pressure to 0.4 g of crude drug per ml; the concentrated solution is centrifuged, and the solution is further concentrated under reduced pressure to a relative density of 1.16 / 60°C. 95% ethanol, measured with an alcohol hydrometer until the alcohol content is 75%, let it stand, centrifuged to obtain a precipitate, and the precipitate was washed with 2 times the weight of absolute ethanol and acetone respectively to obtain 448 grams of polysaccha...

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Abstract

The invention discloses a Chinese magnoliavine fruit polysaccharide extract and a preparation method and an application thereof. Counted by D-glucose, the content of polysaccharides is not lower than 45 percent of the total weight of the polysaccharide extract; a monosaccharide mainly comprises D-glucose, D-galactose and D-galacturonic acid; the mass ratio of the D-glucose to the D-galactose is (3-9):1; and the D-galacturonic acid accounts for 5-40 percent of the total weight of the polysaccharide extract. As proved by mouse ear heterogeneous driven dermal sensitivity test and rat peritoneal mast cell degranulation test, the Chinese magnoliavine fruit polysaccharide extract has remarkable anti-allergic action activity, and can be used for preparing anti-allergic action medicaments, functional foods and cosmetics.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a plant extract, in particular to a polysaccharide extract from Schisandra chinensis and its preparation method and application, in particular to the use of the polysaccharide extract from Schisandra chinensis in the preparation of anti-allergic drugs, functional foods and cosmetics in the application. Background technique [0002] Allergy, also known as hypersensitivity, refers to a specific immune response that occurs when the body responds to certain antigens for the first time and is stimulated by the same antigen again, mainly due to physiological dysfunction or tissue cell damage. A normal immune response is to reject foreign substances and protect the body, while an allergic reaction is an over-reaction of the body to such antigenic substances, which leads to tissue damage and produces varying degrees of harm. [0003] Common allergic diseases: mainly a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K8/97A23L1/29A61P37/08A61Q19/00A23L33/00
Inventor 曾佳烽刘淼潘俊芳朱勤李宝莹陈庆花
Owner SHANGHAI HUATUO MEDICAL SCI CO LTD
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