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Anti-cancer drug

An anticancer drug, m-xylene technology, applied in antibacterial drugs, antineoplastic drugs, drug combinations, etc., can solve the problems of low blood drug content, affecting therapeutic effect, low dissolution rate and absorption rate, etc., and achieve rapid effect , improve the quality of life, increase the effect of absorption and transmission

Inactive Publication Date: 2012-12-19
栾士勋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The administration method of the disclosed compound Chinese patent medicine is mainly oral, because the dissolution rate and absorption rate of the medicine in the gastrointestinal tract are both low, and because the oral dosage is affected by many factors such as gastric volume, gastrointestinal stimulation, individual differences, etc. Due to the influence of restrictive factors, it is difficult to calculate the dosage, and the blood drug content is low and unstable, which seriously affects the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] (1) In the presence of 10g of zinc chloride, 500ml of tert-butanol and 1000ml of hydrochloric acid with a concentration of 36-38wt% are mixed and reacted to obtain tert-butyl chloride;

[0084] (2) In the presence of 8g of aluminum chloride, mix 500ml of tert-butyl chloride with 500ml of m-xylene, and react at a temperature of 30°C-35°C to obtain 5-tert-butyl-m-xylene;

[0085] (3) Mix 500ml of 5-tert-butyl m-xylene with 450ml of nitric acid with a concentration of 65-68wt%, then add 112.5ml of concentrated sulfuric acid, bathe in water for 30min at a temperature of 75°C-90°C, cool to room temperature, and precipitate 2,4 , 6-trinitro-5-tert-butyl m-xylene crystals;

[0086] (4) Mix 2,4,6-trinitro-5-tert-butyl-m-xylene crystals with 5wt% sodium bicarbonate aqueous solution at a mass volume ratio (g:ml) of 1:10, 85- Heat and dissolve at 88°C for 30 minutes, filter, pressurize at 0.2 atmospheres for 40 minutes, and filter again to obtain an anticancer drug infusion injec...

Embodiment 2

[0089] (1) In the presence of zinc chloride, tert-butanol and hydrochloric acid with a concentration of 10wt% are mixed and reacted at a volume ratio of 1:1 to obtain tert-butyl chloride. The mass volume ratio of zinc chloride to hydrochloric acid (g :ml) is 1:60;

[0090] (2) In the presence of aluminum trichloride, mix tert-butyl chloride and m-xylene at a volume ratio of 1:0.5 and react at a temperature of 20°C to obtain 5-tert-butyl m-xylene and aluminum trichloride The mass volume ratio (g:ml) to tert-butyl chloride is 1:50;

[0091] (3) Mix 5-tert-butyl-m-xylene with 10wt% nitric acid at a volume ratio of 1:0.5, then add concentrated sulfuric acid with 1 / 10 volume of nitric acid, put in a water bath at 50°C for 10 minutes, and cool to room temperature. Precipitation of 2,4,6-trinitro-5-tert-butyl m-xylene crystals;

[0092] (4) Mix 2,4,6-trinitro-5-tert-butyl-m-xylene crystals with 2wt% aqueous sodium bicarbonate solution at a mass-volume ratio (g:ml) of 1:3, at 50°C ...

Embodiment 3

[0095] (1) In the presence of zinc chloride, tert-butanol and hydrochloric acid with a concentration of 80wt% are mixed and reacted at a volume ratio of 1:10 to obtain tert-butyl chloride. The mass-volume ratio of zinc chloride to hydrochloric acid (g :ml) is 1:150;

[0096] (2) In the presence of aluminum trichloride, mix tert-butyl chloride and m-xylene at a volume ratio of 1:5 and react at a temperature of 50°C to obtain 5-tert-butyl m-xylene and aluminum trichloride The mass volume ratio (g:ml) to tert-butyl chloride is 1:75;

[0097] (3) Mix 5-tert-butyl-m-xylene with 90wt% nitric acid at a volume ratio of 1:5, then add concentrated sulfuric acid with the same volume of nitric acid, bathe in water at 110°C for 60 minutes, cool to room temperature, and precipitate 2 , 4,6-trinitro-5-tert-butyl m-xylene crystals;

[0098] (4) Mix 2,4,6-trinitro-5-tert-butyl-m-xylene crystals with 10wt% aqueous sodium bicarbonate solution at a mass volume ratio (g:ml) of 1:20, at 100°C He...

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Abstract

The invention relates to an anti-cancer drug, in particular to an anti-cancer drug capable of directionally killing and wounding cancer cells. A main functional ingredient is 2,4,6-trinitro-5-tertiary butyl m-xylene, and a dosage form is a transfusion needle solution which is obtained through heating, dissolving, filtering, pressurizing and re-filtering after the 2,4,6-trinitro-5-tertiary butyl m-xylene is dissolved in a sodium bicarbonate aqueous solution. The anti-cancer drug capable of directionally killing and wounding cancer cells is high in blood concentration, good in therapeutic effect, capable of directionally killing and wounding the cancer cells without damaging normal cells of a human body, and capable of obviously improving self immunity of the human body without toxic and side effects, thereby greatly improving cure rate and survival rate of a cancerous person as well as the survival quality.

Description

technical field [0001] The invention relates to an anticancer drug, in particular to an anticancer drug for directional killing of cancer cells. Background technique [0002] Cancer is the number one killer of human life and health. The report of the World Health Organization shows that in 2008, there were about 12.7 million new cancer patients and 7.6 million deaths from cancer in the world. Especially in developing countries, the number of new cancer cases reached 56%. It is estimated that by 2020, the global incidence of cancer will increase by 50%, that is, 15 million new cancer patients will be added every year. Not only that, but the number of cancer deaths is also rising rapidly around the world, and this number may increase to 13.2 million by 2030. Although humans have invested a lot of manpower and material resources in cancer research for many years, so far no effective means to overcome cancer has been found. How to prevent cancer, improve the cure rate of cancer,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/04A61P35/00A61P29/00A61P31/04A61P31/10A61P31/12C07C205/06C07C201/08
Inventor 栾士勋
Owner 栾士勋
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