Hyodeoxycholic acid

A technology of hyodeoxycholic acid and magnesium oxycholic acid, which is applied in the field of hyodeoxycholic acid and its preparation, can solve the problems of complex production process, large amount of ethyl acetate, long cycle, etc., and achieve shortened production cycle and bile acid free Loss, the effect of less dosage

Inactive Publication Date: 2012-12-26
FUJIAN XIANYOU COUNTY NANFENG BIOCHEM
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Problems solved by technology

The production process is complicated, the cycle

Method used

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  • Hyodeoxycholic acid
  • Hyodeoxycholic acid
  • Hyodeoxycholic acid

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Embodiment Construction

[0019] The content of the present invention is further described in conjunction with the following examples, but the content of the present invention is not limited to the content involved in the examples.

[0020] The preparation technology of hyodeoxycholic acid of the present invention, comprises the steps:

[0021] 1) Crude magnesium hyodeoxycholate extraction fraction (acidification, saponification, decolorization, precipitation):

[0022] Get pig bile filtrate or the pig bile (manufacturer: Xiamen Yixiang Meat United Processing Co., Ltd.) 1000kg after heating and extracting bilirubin, add dilute hydrochloric acid to adjust the pH to 3.0, promptly produce yellow-brown colloidal crude bile acid precipitation, Stand still, pour off the supernatant to obtain crude bile acid. Take it out and rinse the surface acid with water.

[0023] Saponification and hydrolysis of crude bile acid with sodium hydroxide: the weight ratio of the feed is crude bile acid: water: sodium hydrox...

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Abstract

The present invention discloses a hyodeoxycholic acid, which has the following structural formula. According to the present invention, two steps of a crude hyodeoxycholic magnesium extraction part (acidification, saponification, decoloration and precipitation) and a hyodeoxycholic acid purification part (acidification and crystallization) are adopted to obtain the refined hyodeoxycholic acid finished product, wherein a melting point of the hyodeoxycholic acid finished product can be 199-200 DEG C, a melting range is less than 2 DEG C, and content is more than 99%. According to the present invention, a production cycle is greatly shortened, a use amount of the organic solvent is less, and bile acid loss is not substantially generated in the whole process.

Description

technical field [0001] The invention belongs to hyodeoxycholic acid and a preparation process thereof. Background technique [0002] Hyodeoxycholic acid, chemical name: 3α, 6α-dihydroxy-5β-cholanic acid, former name: hyodeoxycholic acid, structural formula as follows: [0003] [0004] Hyodeoxycholic acid is a kind of cholic acid extracted from pig bile, which can inhibit the formation of cholic acid and dissolve fat, reduce blood cholesterol and triglyceride, and is suitable for type IIa or IIb hyperlipidemia and atherosclerosis Sclerosis. It has a certain antibacterial effect on pertussis bacillus, diphtheria bacillus, and staphylococcus aureus. It can be used as an anti-inflammatory drug to treat chronic bronchitis, viral upper respiratory tract inflammation in children, etc. This product can stimulate the secretion of bile and make the bile thinner without increasing the amount of solids. It is suitable for cholangitis, cholecystitis, cholelithiasis and other non-o...

Claims

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Application Information

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IPC IPC(8): C07J9/00
Inventor 彭秋生
Owner FUJIAN XIANYOU COUNTY NANFENG BIOCHEM
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