Method for preparing microspheres by using oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil

A nanoparticle and nanomedicine technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve local microencapsulation and inflammation, incomplete release and burst release, encapsulation Low sealing rate and other problems, to achieve the effect of regular and non-adhesive particles, smooth and round particle surface, and reduce drug burst release
CN102885784BInactive Publication Date: 2014-03-19JINSHAN HOSPITAL FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINSHAN HOSPITAL FUDAN UNIV
Publication Date
2014-03-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing microspheres by using oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil. The method comprises the following steps of: preparing a medicament and medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres, wherein the obtained microspheres comprise the medicament, nanoparticles, the polymer and the medicinal auxiliary materials. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.
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Description

technical field

[0001] The invention relates to a method for preparing drug microsphere preparations, in particular to a method for preparing microspheres from oil-in-oil-in-oil nanometer medicine (N / O / N) in nanoparticle suspension, and belongs to the technical field of pharmacy. Background technique

[0002] In the pharmaceutical industry, from drug discovery to clinical application, the last link is drug preparation. Some of the drugs need long-term administration to be cured, and some of them need targeted and other local administration. To achieve these goals, raw materials must be prepared into corresponding dosage forms. For example, drugs that require long-term administration but have a short half-life in the body should be prepared as sustained-release or controlled-release dosage forms; for the treatment of some tumors, some drugs need to be targeted to the lesion, such as embolization microsphere preparations that target tumor blood vessels, etc. .

[0003] Rega...

Claims

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