Gingerol liposome and preparation method thereof

Abstract

The invention relates to gingerol liposome and a preparation method thereof. The gingerol liposome consists of the following components in parts by weight: 65 to 70 parts of soybean phospholipid, 30 to 35 parts of cholesterol, 0.5 to 30 parts of gingerol, 1000 to 1500 parts of absolute ethanol, and 70 to 120 parts of phosphate buffer solution. The preparation method comprises the following steps of: (1) weighing soybean phospholipid and cholesterol, putting in an eggplant-shaped bottle, and dissolving soybean phospholipid and cholesterol by using absolute ethanol; (2) evaporating the solvent from the eggplant-shaped bottle under reduced pressure; (3) preparing a gingerol solution; (4) forming a gingerol phosphate solution; (5) preparing gingerol liposome suspension; (6) preparing the gingerol liposome by adopting a freeze-drying method; and (7) vacuumizing for 5 to 10 minutes through a freeze drying instrument to sublimate water completely, and thus obtaining gingerol liposome. The preparation method is reasonable in design, the prepared gingerol liposome has very strong in-vitro transdermal absorption performance, and experimental basis is provided for applying the gingerol liposome technology in the biomedicine industry.

Description

Technical field [0001] The invention belongs to the field of biomedicine, in particular to a preparation method of gingerol liposomes with excellent transdermal performance. Background technique [0002] With the rapid development of science, technology, equipment, and methodology, people have a deeper and deeper understanding of themselves. The research on skin physiology and pathology has reached the level of genetic and molecular biology, which has greatly contributed to the development of related biomedical industries. As a driving force, many biologically active animal and plant components and biopolymer components have been applied to the biomedical industry and have achieved huge social and economic benefits. [0003] However, how to apply these biologically active ingredients to the field of biomedicine is faced with many difficulties, mainly in the following aspects: 1. The stability of these biologically active substances is determined by their own structure and spatial c...

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Problems solved by technology

[0003] However, how to apply these biologically active ingredients to the field of biomedicine faces many difficulties, mainly in the following aspects: 1. The stability of these biologically active substances is determined by their own structure and spatial conformation , the influence of external environmental factors should not be underestimated. For example, the active factor solution of the epidermis has a short duration of activity in the external environment for a few hours, and it is basically inactivated before it is absorbed by the skin and cannot play its role at all. Some functions and effects

2. The problem that polymer components are difficult to be absorbed by human skin. Generally speaking, the smaller the molecular weight of the active substance, the easier it is to penetrate the skin. Once the molecular weight is greater than 600, the active substance is difficult to be absorbed by the skin. In recent years, the active substance has Most of the substances with specific skin active functions are macromolecular substances such as peptides, and their molecular weights range from thousands to hundreds of thousands, which determines that they are difficult to penetrate through the skin and be effectively absorbed

3. The solubility of biologically active substances, most of the active ingredients cannot be dissolved in water and absorbed by the skin surface, it is difficult to play their role

[0004] Gingerol can accelerate blood flow, promote sweating, and take away excess heat in the body. It has the effects of detoxification, beauty, and weight loss. However, due to the above reasons, it is difficult to be absorbed by the skin and it is difficult to play its due role.

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