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Puerarin preparation technology

A preparation process, puerarin technology, applied in the field of puerarin preparation technology, can solve the problems of low efficiency, unsuitable for drug separation and purification, cumbersome operation steps, etc.

Inactive Publication Date: 2013-01-30
贾金鑫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the purification method of puerarin is mostly polyamide column chromatography. When the purity is guaranteed to be greater than 97%, the yield is low, only about 1%.
In addition, the polyamide medium is highly toxic and not suitable for the separation and purification of drugs
Some people also use dextran gel chromatography, high-speed counter-current chromatography and macroporous adsorption resin to purify puerarin from the crude extract of Pueraria flavonoids. The operation steps of these methods are cumbersome and inefficient

Method used

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  • Puerarin preparation technology

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Embodiment Construction

[0014] The invention adopts oligomeric cyclodextrin-bonded gel chromatography medium to separate and prepare puerarin from pueraria flavonoids;

[0015] The process steps of the present invention are: sample pretreatment, preparation chromatographic separation process, and product crystallization;

[0016] The process parameters of the present invention are: the concentration of acetic acid is 5%-10%, the preparation flow rate is 5-30ml / min, and the detection wavelength is 200-300nm;

[0017] As a preferred solution, the process parameters are: acetic acid concentration 7%, preparation flow rate 10ml / min, detection wavelength 254nm.

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Abstract

A puerarin preparation technology belongs to the technical field of medicines. The puerarin preparation technology provided by the invention has the advantages of simple operation, high efficiency and non-toxicity. In the invention, puerarin is separated from pueraria flavones through adopting an oligomeric cyclodextrin bonded gel chromatography medium.

Description

Technical field: [0001] A preparation process of puerarin belongs to the technical field of medicine. The process adopts an oligomeric cyclodextrin-bonded gel chromatography medium to separate and prepare puerarin from puerarin flavonoids. Background technique: [0002] Puerarin is a potent natural ingredient extracted from the root of the leguminous plant Puerarin. As a Chinese herbal medicine, kudzu root has complex components, containing more than 50 kinds of various compounds. Among them, pueraria isoflavone (pueraria isoflavone) has a relatively high content of 10% to 14%, and puerarin is the main compound in pueraria isoflavone, and its structural formula is shown in the figure below. Studies in recent years have shown that puerarin can dilate peripheral blood vessels, especially coronary arteries, to dilute blood and improve microcirculation; puerarin also has extensive β-receptor blockade and improves brain and peripheral circulation. It has an important regulatory...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04
Inventor 贾金鑫
Owner 贾金鑫