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Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine

A GM-CSF, furin technology, applied in the field of vaccine development, can solve problems such as damage regulation and effector T cell function

Active Publication Date: 2013-02-06
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to the aforementioned immunosuppressive activity of tumor-secreted TGF-β, it has been found that conditional deletion of endogenously expressed furin in T lymphocytes allows normal T cell development but impairs regulatory and effector T cell function, resulting in less TGF-β1

Method used

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  • Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine
  • Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine
  • Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine

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Embodiment Construction

[0047] While the making and using of various embodiments of the invention are discussed in detail below, it should be appreciated that the present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts. The specific embodiments discussed herein merely describe specific ways to make and use the invention, and do not delineate the scope of the invention.

[0048] In order to facilitate the understanding of the present invention, a number of terms are defined below. Terms defined herein have meanings commonly understood by those of ordinary skill in the fields relevant to the present invention. Terms such as "a", "an" and "the" refer not only to a single entity, but include general categories where specific instances are used for illustration. The terminology described herein is used to describe particular embodiments of the invention, but their usage does not delimit the invention, except as outlined in the claims.

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Abstract

The present invention includes compositions and methods for cancer treatment. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-ss through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.

Description

technical field [0001] The present invention relates generally to the field of vaccine development, and more specifically to the development of methods and compositions for the preparation and use of autologous cancer vaccines genetically modified to knock down furin and express GM-CSF. Background of the invention [0002] Without limiting the scope of the invention, the background of the invention is described in connection with the development of genetically modified whole cell cancer vaccines. More specifically, the present invention relates to vaccines capable of enhancing tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene, and attenuating secretory immunosuppressive activity through furin bifunctional shRNA transgene-induced knockdown. [0003] Popular hypotheses for immune tolerance to cancer vaccines include low immunogenicity of tumor cells, lack of proper presentation by professional antigen-presenting cells, immune sel...

Claims

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Application Information

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IPC IPC(8): A61K31/7105A61K31/711
CPCA61K31/7105A61K31/7088A61K38/217A61P1/04A61P1/16A61P11/00A61P15/00A61P17/00A61P21/00A61P35/00A61P35/04A61P37/04A61K39/001139C12N15/63C12N15/85A61K35/13
Inventor J·J·内姆纳蒂丝N·森泽P·B·梅普尔斯D·拉奥
Owner GRADALIS
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