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Recombinant proteins for use in vaccine, antibodies against said proteins, and diagnostic and therapeutic methods including the same

A protein and antibody technology, applied in the direction of antibody medical components, chemical instruments and methods, anti-bacterial immunoglobulin, etc., can solve the problems of unused commercial vaccines or serological testing

Inactive Publication Date: 2013-02-06
A·罗桑德 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] To date there is no commercial vaccine or serological test for DD

Method used

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  • Recombinant proteins for use in vaccine, antibodies against said proteins, and diagnostic and therapeutic methods including the same
  • Recombinant proteins for use in vaccine, antibodies against said proteins, and diagnostic and therapeutic methods including the same
  • Recombinant proteins for use in vaccine, antibodies against said proteins, and diagnostic and therapeutic methods including the same

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Embodiment approach

[0032] One aspect of the invention relates to an isolated protein having the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 4 or SEQ ID NO: 6, or a fragment or derivative thereof capable of inducing an immune response to said protein, or fragments or derivatives thereof capable of binding antibodies produced by a subject in an immune response to said protein. Said protein, fragment or derivative can be used in veterinary medicine, such as for the prevention of diseases caused by Treponema, such as hoofitis.

[0033] In another aspect, the present invention relates to a method for treating or preventing a disease caused by Treponema comprising administering to a subject an isolated treponema having the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 4 or SEQ ID NO: 6. A protein or a fragment or derivative thereof capable of inducing an immune response against said protein. The method is useful for diseases such as lameness.

[0034] In another aspect, the present invention r...

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Abstract

The present invention relates to proteins and / or fragments and derivatives thereof and their use as vaccines and in biotechnological methods. The vaccines particularly include immunogenic proteins in spp. isolated from digital dermatitis in cattle. The present invention further relates to antibodies raised against said proteins or fragments thereof, and the use of said proteins in diagnostic methods in which antibodies are detected as a sign of digital dermatitis in cattle.

Description

[0001] The present invention relates to proteins and / or fragments and derivatives thereof and their use as vaccines and in biotechnological processes. Said vaccine comprises in particular immunogenic proteins of Treponema spp. isolated from digital dermatitis. The invention further relates to antibodies raised against said protein or fragments thereof, and the use of said protein in a diagnostic method, wherein the antibody is detected as a marker of bovine hoofitis. Background technique [0002] Lameness (DD) is a contagious lameness in cattle that is most common in intensive dairy farms. The disease was first disclosed in Italy in 1974. The first herd with lameness was recently disclosed in Sweden and Bergsten, 2005), whereas previously there were only sporadic, atypical case reports (Manske et al, 2002). There is a strong association between a wet / dirty hoof environment and the incidence of DD (Rodriguez-Lainz et al., 1996), eg accumulation of feces and urine in alleys ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/20A61K39/02A61P31/04C07K16/12G01N33/68
CPCG01N2333/20A61K39/0225C07K14/195G01N33/56911A61P17/00A61P31/04A61P37/04
Inventor A·罗桑德M·普林格尔
Owner A·罗桑德