Double-layer fibrous membrane hernia patch with part being absorbable

A fibrous membrane and double-layer technology, applied in the field of degradable polymer materials and composite materials, can solve problems such as infection and adhesion, and achieve good biocompatibility and tissue compatibility, good cell affinity and tissue compatibility Capacitance, the effect of excellent mechanical strength

Active Publication Date: 2013-02-13
TRANSEASY MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, basically every case of laparotomy has a certain risk of infection and adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A partially absorbable bilayer fibrous membrane hernia mesh was prepared as follows:

[0025] (1) Preparation of solution: PVDF (molecular weight 150000) is dissolved in the mixed solvent of DMF and acetone (volume ratio is 5: 5), is mixed with the electrospinning solution that PVDF concentration is 20wt%; PLGA (molecular weight 60000), Polycaprolactone (molecular weight 60,000) and metronidazole were dissolved in DMF, and prepared into an electrospinning solution with a concentration of 45 wt%, wherein PLGA:PCL=85:15, PLGA:metronidazole=100:5;

[0026] (2) Spinning support base: the PVDF solution obtained in (1) is placed in the feed injector of the multi-spinneret electrospinning machine, the temperature of the spinning environment is controlled to be 50 ° C, and the temperature between the spinneret and the roller is adjusted. The distance is 7-15cm, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr; Turn on the high-voltage power supply and th...

Embodiment 2

[0029] A partially absorbable bilayer fibrous membrane hernia mesh was prepared as follows:

[0030] (1) Preparation of solution: PVDF (molecular weight 250000) is dissolved in the mixed solvent of DMF and acetone (volume ratio is 8: 2), is mixed with the electrospinning solution that PVDF concentration is 15wt%; PLGA (molecular weight 80000), Polycaprolactone (molecular weight 80,000), metronidazole, and 6-aminocaproic acid were dissolved in DMF to prepare an electrospinning solution with a concentration of 35 wt%, wherein PLGA:PCL=90:10, PLGA:metronidazole:6 -Aminocaproic acid=100:2:2;

[0031] (2) Spinning support base: the PVDF solution obtained in (1) is placed in the feed injector of the multi-spinneret electrospinning machine, the temperature of the spinning environment is controlled to be 50 ° C, and the temperature between the spinneret and the roller is adjusted. The distance is 7-15cm, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr; Turn o...

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Abstract

The invention relates to a double-later fibrous membrane hernia patch with a part being absorbable. Polyvinylidene fluoride (PVDF) is used as main materials of a supporting basic layer, polymorphous low-grade adenocarcinoma (PLGA) is used as main materials of a function layer, a small amount of polymer softener and small-molecular drugs are added, and the double-layer fibrous membrane hernia is obtained by solution electrostatic spinning. The double-layer fibrous membrane hernia with the part being absorbable is suitable for being used in various incisional hernias with inflammation or potential adhesions, and has the effects of hemostasis, resist bacterial and adhesion prevention.

Description

Technical field: [0001] The invention relates to the field of degradable polymer materials and composite materials, in particular to a partially absorbable double-layer fiber membrane hernia patch with the functions of hemostasis and anti-adhesion. Background technique: [0002] Hernia is a common complication in surgery. A common hernia treatment is the placement of a hernia mesh where it occurs. At present, it has been clinically proven that polymer mesh hernia mesh has good curative effect, which can reduce the recurrence rate of hernia, relieve pain of patients and improve healing effect. The partially degradable hernia mesh compounded by polypropylene and PLGA shows improved biocompatibility, reduces the body's foreign body rejection, and improves the safety and effectiveness of the hernia mesh application. [0003] At present, the function of the hernia mesh, the most concerned function is still the support function. However, in actual treatment, there are more fact...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/58A61L27/50A61L27/54A61L27/18A61L27/16D04H1/4374D04H1/728
Inventor韩志超许杉杉
OwnerTRANSEASY MEDICAL TECH