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Molecular vector for single molecule detection

A single-molecule detection and molecular technology, applied in the field of molecular carriers, can solve the problems of limited application range, low resolution, unsuitable for low concentration and trace samples, etc., to achieve the effect of improving resolution and accuracy, and enhancing radiation signal.

Active Publication Date: 2013-02-13
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, in the prior art, because the surface of the glass is a flat planar structure, the Raman scattering signal generated is not strong enough, so that the resolution of the single molecule detection is low, and it is not suitable for low concentration and trace samples. detection, thus the application range is limited

Method used

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  • Molecular vector for single molecule detection
  • Molecular vector for single molecule detection
  • Molecular vector for single molecule detection

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preparation example Construction

[0041] The preparation method of the molecular carrier 10 mainly includes: step (S111), providing a mother board 1001; step (S112), forming a three-dimensional nanostructure 102 on the surface of the mother board 1001, forming the substrate 100; step (S113) , forming a metal layer 101 on the surface of the substrate 100 to form the molecular carrier 10 .

[0042] In step ( S111 ), the motherboard 1001 may be an insulating material or a semiconductor material. The material of the motherboard 1001 in this embodiment is silicon dioxide. The thickness of the motherboard 1001 is 200 microns to 300 microns. The size, thickness and shape of the motherboard 1001 are not limited, and can be selected according to actual needs.

[0043] Further, a surface of the motherboard 1001 may be subjected to hydrophilic treatment.

[0044] Firstly, the surface of the motherboard 1001 is cleaned by using a standard cleaning process in a clean room. Then, at a temperature of 30°C~100°C, the volu...

no. 1 example

[0089] Compared with the first embodiment, the molecular carrier 40 provided by the second embodiment of the present invention, since the three-dimensional nanostructure 402 is a raised double-layer cylindrical structure, forms two different distances between adjacent double-layer cylindrical structures. Gap, that is, a gap is formed between adjacent first cylinders 404 , and another gap is formed between adjacent second cylinders 406 . Therefore, when the molecular carrier is used for single-molecule detection, under the excitation of the laser light emitted by the detector, the metal layer 401 in the gap between the adjacent first cylinders 404 generates surface plasmon resonance, while the second The metal layer 401 in the gap between the cylinders 406 produces plasmon resonance, which enhances the Raman scattering on the surface of the metal layer, so that the SERS enhancement factor can be further improved, the Raman spectrum can be enhanced, and the resolution of the sing...

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Abstract

The invention relates to a molecular vector for single molecule detection. The molecular vector comprises a substrate and a metal layer, wherein one surface of the substrate is provided with a plurality of three-dimensional nanostructures; the three-dimensional nanostructures are respectively arranged along a first direction and a second direction at intervals; and the metal layer is coated on the surface of the three-dimensional nanostructures and on the surface of the substrate between adjacent three-dimensional nanostructures.

Description

technical field [0001] The invention relates to a molecular carrier for single molecule detection. Background technique [0002] Single molecule detection (Single Molecule Detection, SMD) technology is different from general conventional detection technology. It observes the individual behavior of a single molecule. Single molecule detection technology is widely used in environmental safety, biotechnology, sensors, food safety and other fields. Single-molecule detection has reached the limit of molecular detection, which has been pursued by people for a long time. Compared with traditional analysis methods, single-molecule detection method studies the individual behavior of the system in the non-equilibrium state, or the fluctuation behavior in the equilibrium state, so it is especially suitable for the study of chemical and biochemical reaction kinetics, biomolecular interactions, structure and Functional information, early diagnosis of major diseases, pathological researc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/55G01N21/65
Inventor 朱振东李群庆张立辉陈墨
Owner TSINGHUA UNIV
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