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Preparation method and application of nine-ingredient notopterygium root tablets

A notopterygium tablet and notopterygium technology, applied in the field of preparation of Jiuwei notopterygium tablet, can solve problems such as rough process, affecting clinical application, and many impurities

Active Publication Date: 2013-03-27
南通市海门江海建设投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Jiuwei Notopterygium Tablets, but the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient Taking it seriously affects the clinical application of this product

Method used

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  • Preparation method and application of nine-ingredient notopterygium root tablets

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Experimental program
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Effect test

Embodiment 1

[0025] Take notopterygium 150g, Fangfeng 150g, atractylodes 150g, asarum 50g, chuanxiong 100g, angelica dahurica 100g, scutellaria baicalensis 100g, licorice 100g, rehmannia glutinosa 100g, add notopterygium, atractylodes atractylodes, asarum and chuanxiong into the CO2 supercritical extractor, ethanol as Entraining agent, the volume percentage of entraining agent in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug·min, and the extraction time is 150min to obtain a supercritical extract for later use; take the rest of the traditional Chinese medicine and pulverize , add 2L of 70% ethanol, put it into a microwave extraction device for microwave extraction, extraction power 400W, extract 2 times, 4 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, wash with 50% ethanol Remove, collect 5 times the column volume eluate, recover ethanol under reduc...

Embodiment 2

[0028] Take notopterygium 150g, Fangfeng 150g, atractylodes 150g, asarum 50g, chuanxiong 100g, angelica 100g, scutellaria baicalensis 100g, licorice 100g, rehmannia glutinosa 100g, add notopterygium, atractylodes, asarum and chuanxiong into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under...

Embodiment 3

[0031] Take notopterygium 150g, Fangfeng 150g, atractylodes 150g, asarum 50g, chuanxiong 100g, angelica 100g, scutellaria baicalensis 100g, licorice 100g, rehmannia glutinosa 100g, add notopterygium, atractylodes, asarum and chuanxiong into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover et...

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Abstract

The invention provides a method for preparing nine-ingredient notopterygium root tablets. The nine-ingredient notopterygium root tablets are prepared by carrying out supercritical extraction and microwave-assisted extraction on the raw material medicines: 150g of notopterygium root, 150g of divaricate saposhnikovia root, 150g of rhizoma atractylodis, 50g of wild ginger, 100g of szechuan lovage rhizome, 100g of radix angelicae, 100g of radix scutellariae, 100g of liquorice, 100g of rehmannia. Therefore, the content of baicalein is greatly improved. The invention also provides application of the nine-ingredient notopterygium root tablets in preparation of medicines for suppressing human cytomegalovirus A549 cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Jiuwei notopterygium tablets. Background technique [0002] Jiuwei Notopterygium Tablets are recorded in the standard WS3-B-0876-91 of the Ministry of Health. It is made of notopterygium 150g, Fangfeng 150g, atractylodes 150g, asarum 50g, chuanxiong 100g, angelica 100g, scutellaria baicalensis 100g, licorice 100g, and rehmannia 100g as raw materials. , can relieve the surface and dehumidify. For aversion to cold and fever, no sweat, headache, dry mouth, sore limbs. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Jiuwei Notopterygium Tablets, but the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient Taking it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/20A61P35/00A61P29/00
Inventor 不公告发明人
Owner 南通市海门江海建设投资有限公司