Traditional Chinese medicine for preventing estrogen deficiency from causing bone loss and preparation method thereof

A technology for estrogen deficiency and bone loss, which is used in pharmaceutical formulations, medical preparations containing active ingredients, bone diseases, etc.

Active Publication Date: 2013-04-17
INST OF BASIC MEDICINE OF SAMS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above-mentioned problems of preventing and treating bone loss caused by estrogen deficiency, the present invention provides a traditional Chinese medicine for preventing and treating bone loss caused by estrogen deficiency and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Rehmannia glutinosa 120g, yam 60g, medlar 60g, dodder 60g, antler gum 60g, tortoise shell gum 60g, psoralen 60g, drynaria fortunei 60g, Eucommia 40g, licorice 30g, soak in 8 times the volume of water, fully soak the medicine for 8 hours , decoct in a high-pressure concentrated decoction machine at 120°C for 90 minutes, and filter out the medicinal liquid; then add 5 times the volume of water, decoct in a high-pressure concentrated medicinal decoction machine at 120°C for 90 minutes, and filter out the medicinal liquid; Combine, heat and concentrate to a relative density of 1.05-1.11, add ethanol to the drug solution until the ethanol concentration is 60%, mix well, precipitate overnight, filter the supernatant; add ethanol to the precipitate until the ethanol concentration is 75%, and mix well , precipitate overnight, and filter the supernatant; add ethanol to the precipitation until the ethanol concentration is 85%, mix well, precipitate overnight, and filter the supern...

Embodiment 2

[0019] Rehmannia glutinosa 60g, yam 40g, medlar 40g, dodder 40g, antler gum 40g, tortoise shell gum 40g, psoralen 40g, drynaria drynaria 40g, eucommia 20g, licorice 20g, soak in 8 times the volume of water, fully soak the medicine for 8 hours , decoct in a high-pressure concentrated decoction machine at 120°C for 90 minutes, and filter out the medicinal liquid; then add 5 times the volume of water, decoct in a high-pressure concentrated medicinal decoction machine at 120°C for 90 minutes, and filter out the medicinal liquid; Combine, heat and concentrate to a relative density of 1.05-1.11, add ethanol to the drug solution until the ethanol concentration is 60%, mix well, precipitate overnight, filter the supernatant; add ethanol to the precipitate until the ethanol concentration is 75%, mix well, Precipitate overnight, filter the supernatant; add ethanol to the precipitation until the ethanol concentration is 85%, mix well, precipitate overnight, filter the supernatant. Mix th...

Embodiment 3

[0021] Rehmannia glutinosa 80g, yam 50g, medlar 50g, dodder 50g, antler gum 50g, tortoise shell gum 50g, psoralen 50g, drynaria fortunei 50g, Eucommia 30g, licorice 20g, soak in 8 times the volume of water, fully soak the medicine for 8 hours , decoct in a high-pressure concentrated decoction machine at 120°C for 90 minutes, and filter out the medicinal liquid; then add 5 times the volume of water, decoct in a high-pressure concentrated medicinal decoction machine at 120°C for 90 minutes, and filter out the medicinal liquid; Combine, heat and concentrate to a relative density of 1.05-1.11, add ethanol to the drug solution until the ethanol concentration is 60%, mix well, precipitate overnight, filter the supernatant; add ethanol to the precipitate until the ethanol concentration is 75%, mix well, Precipitate overnight, filter the supernatant; add ethanol to the precipitate until the ethanol concentration is 85%, mix well, precipitate overnight, filter the supernatant, mix t...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine for preventing estrogen deficiency from causing bone loss. The traditional Chinese medicine is prepared by the following original medicinal materials in parts by weight: 6-12 parts of rehmannia glutinosa, 4-6 parts of rhizoma dioscoreae, 4-6 parts of fructus lycii, 4-6 parts of semen cuscutae, 4-6 parts of colla corni cervi, 4-6 parts of colla plastri testudinis, 4-6 parts of fructus psoraleae, 4-6 parts of rhizoma drynariae, 2-4 parts of cortex eucommiae and 2-3 parts of liquorice. At the same time, the invention provides a preparation method of the traditional Chinese medicine with water extraction and alcohol precipitation. The traditional Chinese medicine takes into account symptoms and root causes all-around and applies tonification and purgation, and has an efficacy of nourishing kidney and strengthening essence and enriching marrow and strengthening bone altogether, so that the purpose of preventing estrogen deficiency from causing bone loss is achieved. The water extraction and alcohol precipitation is adopted by the preparation method of the traditional Chinese medicine to extract active ingredients and removing inactive ingredients in the original medicinal materials, and furthermore, the efficacy of the medicines is increased. The medicine has no obvious toxic and side effects and no obvious taboo when administrating.

Description

technical field [0001] The invention relates to a medicine for preventing and treating bone loss caused by estrogen deficiency, in particular to a traditional Chinese medicine for preventing and treating bone loss caused by estrogen deficiency, and also relates to a preparation method of the traditional Chinese medicine. Background technique [0002] Aging, ovariectomy, low body weight, etc. can all lead to estrogen deficiency, affect bone metabolism through the neuro-endocrine-immune regulatory network, cause bone metabolic diseases such as osteoporosis, bring pain and economic burden to patients, and also cause Medical resources are under enormous pressure. As world population increases and life expectancy increases, bone metabolism disease The threat of the disease will become more and more serious, and according to authoritative estimates, it will increase by 1 to 4 times in the next 10 years. Therefore, the prevention and treatment of this type of disease is an urgent ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P19/08A61P1/14
Inventor 姜国胜李霞王彬姚成芳王丽周宪宾郭钰琪赵向忠张巧凤
Owner INST OF BASIC MEDICINE OF SAMS
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