Medicinal composition for treating chronic hepatitis and liver cirrhosis

A technology for chronic hepatitis and composition, which is applied in the field of pharmaceutical composition and its preparation method and quality control, and can solve the problems of not showing the curative effect of chronic viral hepatitis and the like

Inactive Publication Date: 2013-05-29
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No drug has ever shown a clear and definitive effect on chronic viral hepatitis, so various experimental treatments are still underway

Method used

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  • Medicinal composition for treating chronic hepatitis and liver cirrhosis
  • Medicinal composition for treating chronic hepatitis and liver cirrhosis
  • Medicinal composition for treating chronic hepatitis and liver cirrhosis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0067] Experimental example 1 preparation method experiment of pharmaceutical composition water honey pill of the present invention

[0068] 1. Inspection of crushing process

[0069] 1.1 Crushing conditions

[0070] Instruments and equipment: Pulverizer, produced by Zhigang Pharmaceutical Machinery Factory in Yantai City, Shandong Province, consists of three main parts: ZKF-3 self-controlled pulverizer console, WZS3-470 horizontal rotary sieve and hF3-200 pulverizer; medicinal materials : The above four medicinal materials are all dried in a drying room or an oven until completely dry.

[0071] 1.2 Crushing process

[0072]The crushing efficiency is to crush 20-200kg of medicinal materials per hour, and the sieving particle size can be adjusted arbitrarily between 20-400 mesh. Actually, No. 8 sieve (80 mesh) is used for crushing. Since it is an automatic circulation crushing method, its powder yield It can reach more than 95%.

[0073] 2 Soft material pelletizing process ...

experiment example 2

[0115] Experimental Example 2 Differentiation Experiment of Pharmaceutical Composition Water Honey Pills of the present invention

[0116] Identification (1) [Prescription] Southern Schisandra 1667g, Ligustrum lucidum 500g, Forsythia 500g, Beibaijiang 333g

[0117] [Preparation method] The above four flavors are crushed into fine powder, sieved, and mixed. For every 100g of powder, use 20-30g of refined honey, add appropriate amount of water pan pills, and dry them to make water honey pills.

[0118] [Properties] The honeyed pills of the pharmaceutical composition of the present invention are brown-black honeyed pills; the smell is slight and the taste is slightly sour.

[0119] [identification] (1) get the pharmaceutical composition water honey pill of the present invention, put and observe under the microscope: pericarp epidermis cell surface view class polygon, anticlinal wall thickness is uneven, and cell cavity contains light-colored matter; Staggered vertically.

[01...

experiment example 3

[0156] Experimental example 3 pharmaceutical composition of the present invention (preparation is the same as embodiment 1) honeyed water pill content determination experiment

[0157] 1. Selection of index components for content determination

[0158] One of the main medicinal flavors of the preparation, Schisandra chinensis, is listed as a monarch drug in the prescription. The content limit of schisandrin is determined according to the determination results of three batches of samples. It is known that the lignans represented by schisandrin are its main active ingredients, so it is selected as the content determination object of the pharmaceutical composition water honey pill of the present invention. This quality standard mainly refers to the content determination method of schisandrin A under the item of Shenqi Wuweizi Tablets (Chinese Pharmacopoeia 2005, p.508), and the content determination of schisandrin A, one of the index components of Schisandra chinensis, was carri...

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Abstract

The invention discloses a medicinal composition for treating chronic hepatitis and liver cirrhosis and a preparation method thereof. The composition is mainly prepared from kadsura longepedunculata, glossy privet fruit, weeping forsythia, and sonchus brachyotus which are taken as Chinese herbal medicines. The preparation method comprises the following steps of: grinding adsura longepedunculata, glossy privet fruit, weeping forsythia, and sonchus brachyotus to obtain fine powder, screening, mixing uniformly, adding refined honey, adding water pills and, drying to obtain water-honeyed pills; and adding the conventional auxiliary materials, and preparing the composition in any clinically acceptable formulation by the conventional process. The invention also provides a mass control method for the medicinal composition and application of the mass control method to preparation of the medicine for treating chronic hepatitis and liver cirrhosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and a quality control method thereof, in particular to a pharmaceutical composition for treating chronic hepatitis and liver cirrhosis, a preparation method and a quality control method thereof. Background technique [0002] Chronic hepatitis refers to chronic inflammatory changes in the liver caused by various etiologies, and the course of the disease is at least half a year. Visible jaundice, hypochondriac pain, swelling, accumulation and other manifestations. Usually, the activity of cell enzymes is abnormal, and the enzyme activity in normal human body is relatively stable. Changes in enzyme activity indicate that some organs and tissues of the human body are damaged or some enzymes are released into blood, urine or body fluids after disease occurs. Therefore, the occurrence and development of certain diseases can be understood or judged by the determination of enzyme acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634G01N30/90G01N30/36A61P1/16
Inventor 易毛张诗龙丁晋彪
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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