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Dispersible tablet

A technology of dispersible tablets and loose tablets, applied in the field of dispersible tablets, can solve the problems of slow onset of action and low bioavailability

Active Publication Date: 2014-07-30
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the shortcomings of slow onset of action and low bioavailability of the existing etoposide preparations, the present invention invented etoposide inclusion complex dispersible tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0024] Embodiment 1-6 preparation method is as follows:

[0025] (1) Weighing etoposide and hydroxypropyl β-cyclodextrin at a weight ratio of 1:2, fully grinding them in 50% ethanol, thoroughly grinding, drying, and preparing etoposide inclusion compound;

[0026] (2) After mixing the prescribed amount of disintegrating agent, diluent, flavoring agent and etoposide inclusion complex according to the method of equal addition, add lubricant, glidant, mix evenly, and compress into tablets to obtain etoposide Glycoside inclusion compound dispersible tablet.

[0027]

[0028] Weigh etoposide and hydroxypropyl β-cyclodextrin in a weight ratio of 1:2, grind them fully in 50% ethanol, and grind them thoroughly to obtain a white powder after drying. Poside increased 12-fold.

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Abstract

The invention relates to an etoposide clathrate dispersible tablet. First, etoposide is prepared into a clathrate and then prepared into a dispersible tablet.

Description

technical field [0001] The present application relates to a dispersible tablet, specifically, an etoposide inclusion compound dispersible tablet. Background technique [0002] The dispersible tablet can disintegrate rapidly after being put into water to form a uniformly dispersed suspension, which has the characteristics of convenient use and high bioavailability. The preparation method, production conditions and production process of the dispersible tablet are simple, and the taking method is convenient, and it can be swallowed like a common tablet or dispersed in water for taking. [0003] Etoposide (etoposide) is a semi-synthetic podophyllotoxin derivative, which has broad-spectrum antitumor activity and is clinically used in the treatment of acute leukemia, testicular cancer and small cell lung cancer. However, the absolute bioavailability of oral preparations of etoposide is only 25% to 75%. The poor water solubility of etoposide and its decomposition into inactive pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/7048A61P35/00
Inventor 王明刚陈阳生任莉
Owner CP PHARMA QINGDAO CO LTD