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Rheum officinale extract and application thereof

A rhubarb extract and technology of rhubarb, applied in the fields of application, animal feed, animal feed, etc., can solve the problems of not highlighting the advantages of anthraquinone compounds, unclear mechanism of action, and low bioavailability, so as to improve reproductive ability and quality Fully controllable, detoxifying effect

Inactive Publication Date: 2013-08-07
HUNAN WUJIFENG BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are very few studies on the application of rhubarb extract to animal health care, and most of them focus on its application research on human health care or disease treatment. For example, CN100371001C discloses the use of rhubarb and its extract in the preparation of drugs for lowering postprandial blood sugar , using rhubarb crude drug powder, water or organic solvent extracts to prepare α-glucosidase inhibitor drugs, the extraction process is simple in design, and does not highlight the advantages of anthraquinone compounds as the effective substance basis of rhubarb
The application of rhubarb in animal health care is only involved in compound Chinese herbal medicine feed additives, such as the disclosed natural plant feed additive of CN1352886A, a kind of feed composition and preparation method disclosed by CN102178064A, and the anti-diarrhea compound compound for piglets disclosed by CN01427731A. Chinese herbal medicine feed additives, etc. Rhubarb is added to the feed formula, which provides an important basis for the application of rhubarb in animal health care, but these products have complex composition, uncontrollable quality, low bioavailability, and unclear mechanism of action, etc. defect
There have been no reports on the use of rhubarb extract as a feed additive while highlighting its detoxification and detoxification functions

Method used

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  • Rheum officinale extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Example of preparation of rhubarb extract

[0022] The rhubarb extract of the present embodiment is made by the following method:

[0023] Take 100g of rhubarb rhubarb, crush it, add 1000mL of 10wt% HCl solution, put it in a water bath at 65°C for 3h, filter, wash the filter residue with water until it is neutral, dry it, and reflux extraction with 1000mL of ethanol solution with a volume fraction of 85%, each time for 2h, a total of Repeat the extraction 3 times, after filtration or centrifugation, the liquid part is concentrated to recover ethanol to a concentrated solution with a solid content of 15wt%, and the concentrated solution is spray-dried at 170°C to complete.

[0024] The rhubarb extract prepared in this example has a total anthraquinone content of 43%, and the mass ratio of bound anthraquinone to free anthraquinone is 1:7.

Embodiment 2

[0025] Example 2 Preparation Example of Rhubarb Extract

[0026] The rhubarb extract of the present embodiment is made by the following method:

[0027] Take 100g of dried leaves and stems of Rhubarb palmatum, crush them, add 800mL of 12wt% HCl solution, place in a water bath at 60°C for 2.5h, filter, wash the filter residue with water until neutral, dry it, and reflux extraction with 1500mL of ethanol solution with a volume fraction of 90%. Repeat the extraction 3 times for 2 hours each time. After filtration or centrifugation, the liquid part is concentrated to recover ethanol to a concentrated solution with a solid content of 10wt%, and the concentrated solution is spray-dried at 180°C to complete.

[0028] The rhubarb extract prepared in this example has a total anthraquinone content of 44%, and the mass ratio of bound anthraquinone to free anthraquinone is 1:9.

Embodiment 3

[0029] Example 3 Application of rhubarb extract to detoxify and detoxify in improving reproductive performance of sows

[0030] The rhubarb extract in Example 1 was taken, and the production sows and piglets were taken as test objects to study the effect of rhubarb extracts on the reproductive performance of sows.

[0031] Test time: 2012.04.19-2012.08.20.

[0032] Experimental animals: 62 production sows and piglets.

[0033] Experimental feed: The basic diet was designed according to the National Standard of the People's Republic of China 2002 for pregnant and lactating sows. Control group: whole-course health care, 1 kg of Peptide Lexin + 1 kg of Naijiawang per ton of feed; test group: whole-course health care, adding 500 g of rhubarb extract per ton of feed.

[0034] Test results: When 500g / t rhubarb extract was added to the feed, the production capacity of sows, the production capacity of suckling piglets and the estrus interval of sows were significantly improved. The ...

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Abstract

The invention discloses rheum officinale extract and an application thereof. The rheum officinale extract is prepared by the following method of: crushing the rheum officinale, adding an HCl solution with mass concentration of 10wt%-15wt%, wherein the weight-volume ratio of the rheum officinale powder to the HCl solution is 1:(6g / ml-10g / ml); hydrolyzing for 2-3 hours at 45 DEG C to 65 DEG C, filtering, washing filter residues to neutral by water; refluxing and extracting by an alcohol solution with volume fraction of 85%-95% with extracting time being 2-3 hours once, repeatedly extracting for 3-4 times, partially concentrating liquid to recycle alcohol until the concentrated solution with the solid content of 10wt%-15wt% is obtained after filtering or centrifuging; spraying and drying the concentrated solution under 160 DEG C to 180 DEG C to obtain the rheum officinale extract. The rheum officinale extract disclosed by the invention is added to an animal compound feed for use. The rheum officinale extract disclosed by the invention has the effects of improving intestinal health, improving liver function and promoting detoxification, so that the sow reproductive capacity can be improved. Moreover, the rheum officinale is free of toxic and side effects, free of drug resistance, free of residues in animal products and can be added for a long time.

Description

technical field [0001] The invention relates to a rhubarb extract and its application, in particular to a rhubarb extract and its application in animal detoxification. Background technique [0002] Rhubarb is the general term for perennial herbaceous plants of the Polygonaceae Rhubarb genus. There are 41 varieties and 4 varieties of rhubarb in my country, almost all of which have medicinal value. Among them, only 3 species are included in the Pharmacopoeia as medicinal materials, namely, Rhubarb palmatum and Rhubarb tanguta. Dried roots and rhizomes of yellow and medicinal rhubarb. Rhubarb is mainly distributed in Shaanxi, Gansu, Qinghai, Sichuan, Hubei and Yunnan in my country. Rhubarb is a traditional Chinese medicine in my country. "Shen Nong's Materia Medica" records that rhubarb has the functions of "maintaining blood stasis, closing cold and heat in blood, breaking disease, accumulating, keeping food and food, and cleaning stomach". Modern pharmacological research show...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16A23K1/14
Inventor 贺喜胡瑕杨强张石蕊胡国田
Owner HUNAN WUJIFENG BIOLOGICAL TECH
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