Unlock instant, AI-driven research and patent intelligence for your innovation.

Salvia miltiorrhiza medicine injection preparation containing polyethylene glycol-12-hydroxystearic acid and preparation method of salvia miltiorrhiza medicine injection preparation

A polyethylene glycol lauryl hydroxystearate and injection preparation technology, which is applied in the field of medicine, can solve the problems of Danshen injection, such as precipitation, turbidity, and low allergy, so as to facilitate clinical medication and promotion, and improve clarity degree of effect

Active Publication Date: 2014-03-12
SICHUAN SUNNYHOPE PHARM CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by this invention is to provide a kind of Xiangdan drug injection preparation containing polyethylene glycol lauryl hydroxystearate and its preparation method, which satisfactorily solves the problems of the Danshen injection during storage and high temperature sterilization. It is prone to problems such as precipitation and turbidity, and has the advantages of good stability of the main components and low allergies

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Salvia miltiorrhiza medicine injection preparation containing polyethylene glycol-12-hydroxystearic acid and preparation method of salvia miltiorrhiza medicine injection preparation
  • Salvia miltiorrhiza medicine injection preparation containing polyethylene glycol-12-hydroxystearic acid and preparation method of salvia miltiorrhiza medicine injection preparation
  • Salvia miltiorrhiza medicine injection preparation containing polyethylene glycol-12-hydroxystearic acid and preparation method of salvia miltiorrhiza medicine injection preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Accurately weigh 800g of Salvia miltiorrhiza and 800g of radix radix; add radix radix to infiltrate with water, carry out steam distillation, collect about 500ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, and collect the aqueous solution in another device. Add dan to the water and decoct three times, add 8 times the amount of water for the first time, and decoct for 2 hours; add 6 times and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoction, filter, and the filtrate Concentrate to 670-760ml, add ethanol to make the alcohol content reach 75%, let it stand for 40 hours, filter, recover ethanol from the filtrate, concentrate to about 330ml, add ethanol to make the alcohol content reach 85%, let it stand for 40 hours, in Add 1% activated carbon to the solution by volume, stir for 1 hour, filter, recover ethanol from the filtrate, concentrate to 200-300ml, add 1000-1650ml of water f...

Embodiment 2

[0019] Accurately weigh 800g of Salvia miltiorrhiza and 1200g of radix radix; add radix radix to infiltrate with water, carry out steam distillation, collect about 500ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, and collect the aqueous solution in another vessel. Add dan to the water and decoct three times, add 8 times the amount of water for the first time, and decoct for 2 hours; add 6 times and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoction, filter, and the filtrate Concentrate to 670-760ml, add ethanol to make the alcohol content reach 75%, let it stand for 40 hours, filter, recover ethanol from the filtrate, concentrate to about 330ml, add ethanol to make the alcohol content reach 85%, let stand for 40 hours, in Add 1% activated carbon to the solution by volume, stir for 1 hour, filter, recover ethanol from the filtrate, concentrate to 200-300ml, add 1000-1650ml of water for...

Embodiment 3

[0021] Accurately weigh 1000g of Salvia miltiorrhiza and 1000g of radix radix; the above two flavors, add radix radix to infiltrate with water, carry out steam distillation, collect about 500ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, and collect the aqueous solution in another container. Add dan to the water and decoct three times, add 8 times the amount of water for the first time, and decoct for 2 hours; add 6 times and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoction, filter, and the filtrate Concentrate to 670-760ml, add ethanol to make the alcohol content reach 75%, let it stand for 40 hours, filter, recover ethanol from the filtrate, concentrate to about 330ml, add ethanol to make the alcohol content reach 85%, let stand for 40 hours, in Add 1% activated carbon to the solution by volume, stir for 1 hour, filter, recover ethanol from the filtrate, concentrate to 200-300ml, a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a salvia miltiorrhiza medicine injection preparation containing polyethylene glycol-12-hydroxystearic acid and a preparation method of the salvia miltiorrhiza medicine injection preparation. The salvia miltiorrhiza medicine injection preparation is a medicament which is mainly prepared by dissolving a salvia extract, a dalbergia wood extract and polyethylene glycol-12-hydroxystearic acid for improving the clarity of the injection into water for injection, wherein the use amount of the polyethylene glycol-12-hydroxystearic acid is 1.5-2.0g / 100ml. According to the salvia miltiorrhiza medicine injection preparation, the detection of visible foreign matters of the injection can be stably kept to accord with the provision of pharmaceutical quality standard, the clarity of the salvia miltiorrhiza medicine injection preparation can be improved, and the problems that the salvia miltiorrhiza injection is easy to generate precipitation, turbidness and the like in the storage and high-temperature stabilization process are solved; and meanwhile, the salvia miltiorrhiza medicine injection preparation has the advantages of good stability of main ingredients, low sensitivity and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine injection preparation of Xiangdan containing polyethylene glycol lauryl hydroxystearate and a preparation method thereof. Background technique [0002] The standard of Xiangdan injection is recorded in the drug standard issued by the Ministry of Health (WS3-B-3289-98, traditional Chinese medicine preparation), and the raw materials are Danshen and Jiangxiang. Xiangdan injection has the effect of dilating blood vessels and increasing coronary blood flow. It is clinically used to treat angina pectoris, and can also be used for myocardial infarction. According to the quality standard preparation method of Xiangdan injection, the main components of Salvia miltiorrhiza extract and Jiangxiang extract are complex, and contain volatile oil of Jiangxiang that is insoluble in water, which makes Xiangdan injection easy to store and sterilize at high temperature. Pr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/08A61K9/19A61K47/34A61P9/10
Inventor 陈开军郭成辉廖远征黄筱萍毛长兴
Owner SICHUAN SUNNYHOPE PHARM CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com