Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers

A kind of nanocarrier, conjugate technology

Inactive Publication Date: 2013-08-28
MALLINCKRODT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Unfortunately, obstacles still exist in the preparation of nanocarrier-based products that can effectively treat or diagnose cancer

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  • Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers
  • Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers
  • Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers

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[0034] II. Overview

[0035] The present invention provides targeted delivery compositions and methods of their use for treating and diagnosing disease states in a subject. The disclosed compositions and methods provide a number of beneficial features over prior methods. For example, the targeted delivery composition includes a linker that can be synthesized with a discrete number of monomers that can be tailored, eg, to provide a particular length and / or chemical properties. Furthermore, the monomers making up the linker are fully customizable and can be prepared to include only one type of monomer or multiple types of monomers in any order. The linker can also be synthesized on a solid support, which allows simple, automated synthesis. In addition to the linker, the targeted delivery composition can be used to treat diseases more effectively by using lower doses of drugs that would be toxic to the patient if administered at normal doses.

[0036] III. Targeted Delivery Co...

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Abstract

The present invention provides targeted delivery compositions and their methods of use in treating and diagnosing a disease state in a subject. In one aspect, the targeted delivery compositions of the present invention can include a targeted delivery compositon, comprising: (a) a nanocarrier including a therapeutic or diagnostic agent or a combination thereof; and (b) a conjugate having the formula: A- [(EG) (P)]n-T; wherein, A is an attachment component for attaching the conjugate to the nanocarrier; [(EG) (P)]n is a linking group, wherein the subscript n is an integer from 1 to about 40; and each EG is independently selected from a group consisting of triethylene glycol, tetraethylene glycol, pentaethylene glycol, hexaethylene glycol, heptaethylene glycol, and octaethylene glycol; P is independently selected from a group consisting of phosphate and thiophosphate; and, T is a targeting agent.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application 61 / 386,201, filed September 24, 2010, which is hereby incorporated in its entirety. [0003] Statements Regarding Inventors' Rights Made Under Federally Sponsored Research and Development Not Applicable [0004] Attachments Regarding "Sequence Listings", Tables or Computer Program Listings Submitted on CD-ROM Not Applicable Background technique [0005] Cancer is a group of diseases that can affect people of all ages. Accordingly, there is a significant effort to provide therapies that can treat or diagnose cancer in patients. Targeted delivery of nanocarriers in vivo has recently been discussed as a potential new avenue in drug delivery and diagnostic imaging techniques. Unfortunately, obstacles still exist in the preparation of nanocarrier-based products that can effectively treat or diagnose cancer. Therefore, there is a need for new targeted delivery ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48
CPCA61K9/1271A61K47/60A61K47/50A61K47/51A61K47/549A61K47/554A61K47/56A61K47/6911A61P35/00A61K9/127A61K9/16A61K49/08A61K51/02
Inventor B.N.特拉维克T.A.欧西克小詹姆斯.R.惠特利
Owner MALLINCKRODT INC
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