Metabolic targeting of cancer cells using chemotherapy and immunotherapy for the treatment of cancer

A technology of immunotherapy and cancer, applied in chemical instruments and methods, metabolic diseases, immunoglobulin, etc., can solve problems such as failure, interference, and long-term immunosuppression

Active Publication Date: 2018-05-25
汤姆 C 臧
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Repeated or high-dose cycles of chemotherapy may cause severe stem cell depletion leading to long-term immunosuppression or failure
Immunosuppression and other side effects often limit the dose or frequency of treatment, interfere with other treatments used in combination with chemotherapy, or otherwise cause interruptions in cancer treatment and progression of the disease

Method used

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  • Metabolic targeting of cancer cells using chemotherapy and immunotherapy for the treatment of cancer
  • Metabolic targeting of cancer cells using chemotherapy and immunotherapy for the treatment of cancer
  • Metabolic targeting of cancer cells using chemotherapy and immunotherapy for the treatment of cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Example 1: Metabolic Targeted Chemotherapy Has Beneficial Clinical Effects

[0131] patient. Six patients with several metabolically advanced cancers (i.e. stage IIIB / IV) that had not previously responded to standard treatment with one or more chemotherapeutic agents, radiation, surgery, or other forms of treatment were selected and performed as follows treat.

[0132] treatment solutions. Before treatment, patients were imaged by computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), or a combination thereof, and baseline tumor mass was calculated. On Day 0, patients are fasted overnight to achieve baseline glucose levels (typically about 4.5-5.5 mmol / L). The next day (Day 1), after an initial IV infusion with 500 cc of saline, all patients received insulin (Humalog) intravenously (i.v.) at a dose of 0.1 to 0.5 units / kg body weight to lower blood glucose levels to baseline About half of the level (about 2.2-2.8mmol / L). ...

Embodiment 2

[0144] Example 2: Metabolic Targeted Chemoimmunotherapy for the Treatment of Cancer

[0145] patient. Select patients with several metabolically advanced cancers (i.e., stage IIIB / IV; cancer types are shown in Table 4 below) that have not previously responded to standard treatment with one or more chemotherapeutic agents, radiation, surgery, or other forms of treatment Patients who were treated at No. 383 Changying East Road, Xi'an Xincheng Borui Hospital and Yangling Demonstration Area Hospital were treated as described below.

[0146] treatment solutions. Before treatment, patients were imaged by computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), or a combination thereof, and baseline tumor mass was calculated.

[0147] On day 0, the patient is administered an immunizing agent such as a therapeutic antibody or functional fragment thereof. Therapeutic antibodies that may be used in this treatment regimen may include commerci...

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Abstract

Provided herein are methods for treating cancer comprising administering a metabolically targeted chemo-immunotherapy regimen. In one embodiment, a metabolically targeted chemo-immunotherapy regimen may comprise the step of administering a therapeutically effective dose of one or more immunizing agents (e.g., therapeutic antibodies) in a subject with cancer to stimulate immune responding; reducing blood glucose levels in the patient; and administering a therapeutically effective dose of one or more chemotherapeutic agents. The methods described herein are useful in the treatment of any type of cancer, particularly malignant and metastatic advanced cancers.

Description

[0001] priority statement [0002] This application claims the benefit of US Provisional Application No. 61 / 420,208, filed December 6, 2010, which is hereby incorporated by reference in its entirety as if set forth in its entirety herein. Background technique [0003] Cancer is the leading cause of death worldwide. In the United States alone, more than 1.3 million people are diagnosed with cancer and more than 500,000 die each year. Due to high morbidity and mortality, research efforts have focused on improving treatment options for those already diagnosed with cancer, but a cure has been elusive, especially in the advanced stages of the disease. [0004] Treatment options are determined based on the type and stage of cancer and the patient's overall health. Several treatment options are available, including surgery, chemotherapy, radiation therapy, targeted therapy, and immunotherapy. Sometimes early-stage primary tumors are treated with surgery followed by radiation thera...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/475A61K31/282A61K31/513A61K31/704A61K31/7048A61K38/28A61K39/395A61K45/00A61P35/00A61P35/04A61K33/243
CPCA61K31/155A61K31/277A61K31/36A61K31/407A61K31/475A61K31/49A61K31/513A61K31/519A61K31/555A61K31/64A61K31/675A61K31/704A61K31/7048A61K31/7068A61K39/39558A61K45/06A61K38/28C07K16/2863C07K16/32A61K38/191A61K38/193A61K38/2026A61K38/217A61K2039/545A61K31/4745A61K31/573A61P35/00A61P35/02A61P35/04A61P37/04A61P43/00A61P3/10A61K33/243A61K2300/00A61K33/24
Inventor 汤姆·C·曾琳达·米德-托林迈克尔·E·彭宁顿
Owner 汤姆 C 臧
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