Compound clobetasol propionate lipid composite ointment and preparation method thereof

Abstract

The present invention provides a clobetasol propionate and tretinoin ointment agent. According to the present invention, a phospholipid and a positively charged lipid are mainly adopted to wrap drugs to prepare a lipid complex, wherein the positively charged lipid complex can concurrently wrap two drugs, encapsulation efficiency is high, and leakage is not easily generated; with the lipid complex, drug absorption can be promoted, and drug retention in skin can be increased; the multi-component low co-melting system is adopted to prepare the solid dispersion, such that the composite antioxidant component in the formula is uniformly dispersed in the same system; an oil phase matrix and an emulsifying agent are added so as to further prepare into a cream agent or an ointment agent in one step; and the preparation has characteristics of good emulsifying uniformity and high stability, and can be used for treatment of psoriasis, chronic dermatitis and eczema, skin papule type amyloidopathia, lichen planus, and non-atopic dermatitis.

Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to a compound clobetasol propionate and all-trans retinoic acid lipid complex and a preparation method thereof. The lipid complex has the characteristics of high skin penetration and high skin drug retention Features, can be further prepared into cream, ointment, mainly used for the treatment of psoriasis vulgaris, dermatitis, eczema and other diseases. Background technique

[0002] Both clobetasol propionate and retinoic acid are commonly used topical dermatological treatments with definite curative effects. Clobetasol propionate (CP) is a powerful hormone, long-term use can cause side effects such as skin atrophy, and the side effect commonly used in the use of tretinoin is skin irritation. In addition, transdermal absorption of drugs into the blood circulation system will produce systemic toxic and side effects. Therefore existing open technology is devoted to utilizing c...