Degradable compound active amnion material, preparation method and application thereof and compound active amnion uterine cavity repair stent

Abstract

The invention provides a compound active amnion material, a preparation method and application thereof and a compound active amnion uterine cavity repair stent. The preparation method comprises the following steps: (1) providing a collagen sponge prepare liquid or a compound collagen sponge prepare liquid; (2) providing an amnion with both an epithelial layer and a basement membrane; (3) pouring and coating the prepared prepare liquid on the basement membrane of the amnion to enable the basement membrane and the prepare liquid to be subject to crosslinking, and then preparing the compound active amnion material through freeze drying. The compound active amnion material not only keeps the complete structure and the due biological function of the amnion but also endow the amnion with a certain rigidity, so that the compound active amnion material has stronger maneuverability in application after TCRA (Transcervical Resection Of Adhesions) operation; the compound active amnion uterine cavity repair stent integrates the compound active amnion material and a saccule at the front end of a pipe body, the saccule expands under the action of an external force to push out the compound active amnion material, and then the compound active amnion material is successfully attached to the inner wall of the uterine cavity; the stent is convenient to take out and prevents secondary damage.

Description

technical field [0001] The invention relates to the technical field of gynecological intrauterine adhesion treatment, more particularly to a degradable composite active amniotic membrane material, a preparation method and application thereof, and a composite active amniotic membrane uterine cavity repair stent. Background technique [0002] Intrauterine adhesions (IUA), also known as Asherman syndrome, refers to the mutual adhesion of the uterine muscle wall and / or the cervical canal after damage to the uterine cavity or the endometrium of the cervical canal due to various factors. Affect menstruation and reproductive function in women of childbearing age. Trauma, infection, uterine malformation and genetic predisposition to the uterine cavity during pregnancy and non-pregnancy are the main reasons for the formation of intrauterine adhesions. The main histopathological changes of intrauterine adhesions are endometrial fibrosis and scarring. Clinically, intrauterine adhesion...

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a degradable composite active amniotic uterine cavity repair bracket, so as to solve the problem of inflammation caused by the inability to effectively separate the front and rear walls of the uterus in the prior art, thereby accelerating postoperative adhesion; the removal of the metal bracket will cause secondary damage to the human body ; The effect of drug treatment on patients with severe IUA is not optimistic, and the postoperative re-adhesion rate is over 50%; it does not have the function of promoting endometrial regeneration and repair;

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