Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Nardoaristolones A in preparing medicines for treating rheumatoid arthritis

An arthritic and rheumatoid technology, applied in the field of compounds, can solve the problems of poor selectivity of action, ulcers, easy to induce infection, etc., and achieve the effect of outstanding substantive characteristics and strong inhibitory activity

Active Publication Date: 2015-05-20
SHANGHAI STEPPHARM CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Nardoaristolones A in preparing medicines for treating rheumatoid arthritis
  • Application of Nardoaristolones A in preparing medicines for treating rheumatoid arthritis
  • Application of Nardoaristolones A in preparing medicines for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Nardoaristolones A tablet involved in the present invention:

[0013] Take 5 grams of compound Nardoaristolones A, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Nardoaristolones A capsules involved in the present invention:

[0015] Get 5 grams of compound Nardoaristolones A, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1, the influence of Nardoaristolones A of the present invention on rat adjuvant arthritis

[0018] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind foot of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally administered Nardoaristolones A5.0, 10.0, and 20.0 mg / kg of the present invention, and the positive control group was orally administered Diclofenac 10mg / kg, the control group was given the same volume of distilled water, once...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to Nardoaristolones A for treating immune inflammation and the Nardoaristolones can be used for preparing medicines for treating rheumatoid arthritis. Terfenadine and diclofenac sodium are taken as control, and the curative effect of Nardoaristolones A is exact. The use of Nardoaristolones A for preparing medicines for treating rheumatoid arthritis provided by the invention is disclosed for the first time. As the framework type belongs to a brand-new framework type, Nardoaristolones A has remarkable substantive characteristics and obviously has remarkable progress for preventing and treating rheumatoid arthritis.

Description

technical field [0001] The present invention relates to the new use of compound Nardoaristolones A, in particular to the application of Nardoaristolones A in the preparation of medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a clinical common disease and frequently-occurring disease. Rheumatoid arthritis belongs to autoimmune disease and belongs to the category of immune inflammation. At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection. Therefore, compounds with well-defined components, controllable quality, safety and high efficiency have potential value in the development of drugs for rheumatoid arthritis. [0003] The compound Nardoaristolones A involved in the present invention is published in 2013 (Ming-Li Liu, Ying...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P19/02A61P29/00
Inventor 张延
Owner SHANGHAI STEPPHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com