Interbody fusion cage and method for preparing same

Abstract

The invention discloses an intervertebral fusion device and a preparation method thereof. The weight percentage of the specific composition is: 20-40% poly-DL-lactic acid (PDLLA), 30-50% poly-L-lactic acid / glycolic acid copolymerization (L-PLGA), 10-30% hydroxyapatite (HA) and 5-10% tricalcium phosphate (β-TCP). The fusion device of the present invention has high strength, good osteoinductive activity, can be completely degraded and absorbed in vivo, and is a new generation of absorbable intervertebral fusion device with high strength and high bone fusion rate that can meet clinical application requirements.

Description

technical field [0001] The invention belongs to the technical field of medical material manufacturing, and in particular relates to a high-strength bioactive absorbable intervertebral fusion device and a preparation method thereof. Background technique [0002] The intervertebral disc herniation and intervertebral instability caused by spinal degeneration are common and frequently-occurring diseases that plague human beings in today's society. After intervertebral disc herniation, it often causes instability between the vertebral bodies or narrowing of the intervertebral space. The intervertebral disc herniation compresses the nerves and causes long-term pain, which seriously affects the work and life of the patient. Over time, spondylolisthesis may occur , and even more serious consequences such as paralysis. Patients who do not respond to conservative treatment usually require intervertebral fusion surgery. Autologous bone grafting is the gold standard for spinal fusion,...

AI Technical Summary

Problems solved by technology

[0003] There are currently the following types of materials for making intervertebral fusion cages: the first clinically used intervertebral fusion cages are metal materials, and most of the current clinically used ones are Titanium alloy fusion cages, such as Harms, BAK, TFC fusion cages, etc., although metal fusion cages have good histocompatibility and high support strength, in clinical applications, the elastic modulus is too high, which may cause compression of the vertebral body. Possibility of displacement or detachment; it remains in the body for a long time and requires a second operation to remove it; at the same time, the internal bone fusion cannot be judged from the X-ray film

In order to overcome the above shortcomings, intervertebral fusion cages made of non-metallic materials such as polycarbon fiber and polyether ether ketone (PEEK) bioplastics have been used. The human body degrades and absorbs; at the same time, the tiny particles produced after its wear and tear can cause local inflammatory reactions in the surrounding tissues

[0004] Chinese Patent Publication Nos. CN1436518A and CN2561364A respectively announced the development process of fusion devices made of polylactic acid or added hydroxyapatite, but their strength and degradation performance Still needs to be further improved, while the cage lacks osteogenic activity

However, the product still has the disadvantages of unstable mechanical properties, poor bone conduction ability, and inappropriate degradation rate.

Chinese Patent Publication No. CN101450015A relates to an intervertebral fusion device made of polylactic acid / glycolic acid copolymer PLGA and hydroxyapatite, but its strength is not as good as that of PDLLA homopolymer

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