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Applications of Sarcaboside A in medicament against human fungus

An antifungal and drug technology for human body, applied in the direction of antifungal agents, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of digestive tract irritation, strong accumulation of toxicity, etc. active effect

Inactive Publication Date: 2013-12-18
NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Applications of Sarcaboside A in medicament against human fungus
  • Applications of Sarcaboside A in medicament against human fungus
  • Applications of Sarcaboside A in medicament against human fungus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Sarcaboside A tablet involved in the present invention:

[0013] Take 20 grams of compound Sarcaboside A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Sarcaboside A capsule involved in the present invention:

[0015] Get 20 grams of compound Sarcaboside A, add conventional adjuvants for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Sarcaboside A anti-fungal activity in humans

[0018] Anti-human fungus activity experiment is the method of concentration dilution, each determination is repeated three times, the test pathogens are Trichophyton rubrum, Microsporum lanoides and Trichophyton aureus, and the concentration of bacteria solution is 10 5 individual / mL. The initial concentration of Sarcaboside A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the same volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the human fungal culture temperature 28 ℃ respectively, observe after 24 hours of incubation time, if no colony is found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Sarcaboside A against human fungi are shown in Table 1.

[0019] Table 1 Sarcaboside A anti-human fungal MIC value (μ...

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Abstract

The invention relates to applications of Sarcaboside A in preparing a medicament against human fungus, and belongs to the field of medicines. The Sarcaboside A plays a strong role in inhibiting trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, therefore, the Sarcaboside A can serve as a compound with an anti-human fungus function, and is expected to be applied in preparing related medicaments. The applications of the Sarcaboside A in preparing the medicament against human fungus are disclosed for the first time. As a skeleton type of the Sarcaboside A belongs to a brand-new skeleton type, the Sarcaboside A has an unexpectedly strong human fungus inhibition activity, and the possibility of giving any inspiration by other compounds does not exist. The Sarcaboside A has significantly substantive characteristics, as well as obviously prominent progress in the prevention and treatment of the human fungus infection.

Description

technical field [0001] The present invention relates to the application of Sarcaboside A, in particular to the application of Sarcaboside A in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Sarcaboside A inv...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P31/10
Inventor 江春平张广
Owner NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH
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