Application of spirooliganones B in preparation of medicine inhibiting platelet aggregation
An anti-platelet aggregation and drug technology, applied in the direction of drug combination, blood diseases, pharmaceutical formulations, etc., can solve urgent problems, minor adverse reactions, etc.
Inactive Publication Date: 2015-06-17
SUZHOU CHENCAI TEXTILE RES & DEV
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Currently commonly used antiplatelet drugs have severe adverse reactions, so it is urgent to develop new effective drugs for the treatment and prevention of platelet aggregation with less adverse reactions
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0012] Embodiment 1: the preparation of compound Spirooliganones B tablet involved in the present invention:
[0013] Take 5 grams of compound Spirooliganones B, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.
Embodiment 2
[0014] Embodiment 2: the preparation of compound Spirooliganones B capsules involved in the present invention:
[0015] Take 5 grams of compound Spirooliganones B, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.
[0016] The following pharmacodynamic experiments will further illustrate its drug activity.
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The invention relates to the application of spirooliganones B in preparation of the medicine inhibiting the platelet aggregation. The application of spirooliganones B in preparation of the medicine inhibiting the platelet aggregation is disclosed for the first time. The spirooliganones B belongs to a brand new matrix type, has the advantages of being high in activity for inhibiting the platelet aggregation and prominent in substantive features, and makes remarkable progress in inhibiting the platelet aggregation.
Description
technical field [0001] The present invention relates to the new application of the compound Spirooliganones B, in particular to the application of the Spirooliganones B in the preparation of anti-platelet aggregation drugs. Background technique [0002] The basic physiological functions of platelets are adhesion, aggregation, release and secretion of granule contents (such as ATP, 5-hydroxytryptamine). After activation, platelets can provide a phospholipid surface, promote blood coagulation, and form a thrombus composed of fibrin surrounding platelets. Therefore, as a formed component of blood, platelets play a very important role in the process of physiological hemostasis and pathological thrombus formation. Clinical studies have shown that common cardiovascular and cerebrovascular diseases such as hypertension, angina pectoris, myocardial infarction, cerebral infarction and cerebral hemorrhage are basically related to changes in platelet function and abnormal hemorheology...
Claims
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IPC IPC(8): A61K31/352A61P7/02
Inventor 赵巧英
Owner SUZHOU CHENCAI TEXTILE RES & DEV