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Preparation method and application of qianbai rhinitis tablets

A technology for Qianbo rhinitis tablets and Selaginella cypress, which is applied in the field of preparation of Qianbo rhinitis tablets, can solve the problems of large dosage for patients, rough process, backwardness and the like, and achieve the effect of reducing the dosage.

Inactive Publication Date: 2015-06-24
SUZHOU CHENCAI TEXTILE RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about the use of supercritical technology in the extraction and preparation of Qianbai Biyan Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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  • Preparation method and application of qianbai rhinitis tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take Senecio 2424g, Selaginella 404g, Notopterygium 16g, Semen Cassiae 242g, Ephedra 81g, Ligusticum Chuanxiong 8g, Angelica dahurica 8g into the CO2 supercritical extractor, ethanol is used as entrainer, the entrainer accounts for 4% by volume of the total extraction solvent, Extraction pressure 15MPa, temperature 30°C, CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 1000 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take Senecio 2424g, Selaginella 404g, Notopterygium 16g, Cassia 242g, Ephedra 81g, Chuanxiong 8g, Angelica dahurica 8g into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Starch and 70% ethanol are added to make granules, dried, and pressed into tablets to make 1000 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take Senecio 2424g, Selaginella 404g, Notopterygium 16g, Cassia 242g, Ephedra 81g, Chuanxiong 8g, Angelica dahurica 8g into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 1000 tablets, each weighing 0.5g. Example 4: Experimental Research Data of Qianbai Biyan Tablets Inhibiting A-204 Cell Proliferation

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Abstract

The invention provides a preparation method of qianbai rhinitis tablets. The qianbai rhinitis tablets are prepared by performing supercritical extraction on 2424 g of groundsel, 404 g of selaginella tamariscina, 16 g of notopterygium root, 242 g of semen cassiae, 81 g of ephedra, 8 g of ligusticum wallichii and 6 g of angelica dahurica serving as raw materials, so that the content of each raw material is greatly improved, and the dose is reduced. The invention also provides application of the qianbai rhinitis tablets in preparation of a medicament for inhibiting the cell proliferation of rhabdomyosarcoma A-204.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Qianbai Biyan Tablets. Background technique [0002] Qianbai Biyan Tablets are recorded in the Pharmacopoeia, and the prescription is Senecio 2424g, Selaginella 404g, Notopterygium 16g, Cassia 242g, Ephedra 81g, Chuanxiong 8g, Angelica dahurica 8g, the above seven flavors, notopterygium, Chuanxiong, and Angelica dahurica are crushed into fine powder; the rest of Senecio, etc. Add water to decoct the four flavors twice, combine the decoction, filter, concentrate the filtrate into a thick paste, add the above-mentioned notopterygium, chuanxiong and other fine powders, mix well, dry, crush into fine powder, make granules, press into 1000 tablets, pack Sugar-coated and served. Can clear away heat and detoxify, promote blood circulation and expel wind, clear the lung and unblock the orifices. It is used for co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/482A61K9/20A61P11/02A61P35/00
Inventor 不公告发明人
Owner SUZHOU CHENCAI TEXTILE RES & DEV