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Preparation method and application of compound danshen tablets

A technology of compound Danshen tablets and Danshen, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of large dosage, backwardness, and many impurities for patients, and achieve the effect of reducing dosage

Inactive Publication Date: 2014-01-08
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Compound Danshen Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients, which is inconvenient to take, and seriously Affected the clinical application of this product

Method used

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  • Preparation method and application of compound danshen tablets

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Effect test

Embodiment 1

[0016] Take 450g of Danshen, 141g of Panax notoginseng, and 8g of borneol and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take 450g of Danshen, 141g of Panax notoginseng, and 8g of borneol and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 450g of Danshen, 141g of Panax notoginseng, and 8g of borneol and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method of compound danshen tablets. The compound danshen tablets are prepared from 450g of danshen, 141g of pseudo-ginseng and 8g of borneol which are used as raw medicinal materials by adopting a supercritical extraction method, so that the content is greatly increased and the intake dosage is reduced. The invention also provides an application of the compound danshen tablets in preparation of a medicament for restricting cell proliferation of mouse melanoma cells B16.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of compound salvia miltiorrhiza tablets. Background technique [0002] Compound Danshen Tablets are recorded in Pharmacopoeia, the prescription is 450g of Danshen, 141g of Panax notoginseng, 8g of borneol, the above three flavors, extraction of Danshen three times, adding ethanol to reflux for 1.5 hours for the first time, filtering, recovering ethanol from the filtrate, and concentrating to a relative density of 1.30 (55~ 60°C); add 50% ethanol for the second time to reflux for 1.5 hours, filter; add water for the third time to reflux for 2 hours, filter, combine the second and third filtrates, recover ethanol, concentrate to a relative density of 1.40 (55-60°C) , combined with the concentrated solution for the first time, and mixed evenly to make a clear paste with a relative density of 1.35-1.39 (55°C). Gr...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61P35/00A61K31/045
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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