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Preparation method and application of purified coronary disease particle

A technology of Guanxin Granules and Radix Paeoniae Rubra, applied in the field of preparation of refined Guanxin Granules, which can solve the problems of large dosage for patients, rough process, and impact on clinical application, and achieve the effect of reducing dosage

Inactive Publication Date: 2014-01-22
王玮玮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of refined Guanxin Granules. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients, which is inconvenient to take and seriously affects This product has been applied clinically

Method used

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  • Preparation method and application of purified coronary disease particle

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Effect test

Embodiment 1

[0016] Take 456g of Salvia miltiorrhiza, 228g of red peony, 228g of Chuanxiong, 228g of safflower, and 152g of Jiangxiang, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, and the extraction time is 150min to obtain supercritical extract, add starch, 70% ethanol to make granules, and dry to make 650g.

Embodiment 2

[0018] Take 456g of Salvia miltiorrhiza, 228g of red peony, 228g of Chuanxiong, 228g of safflower, and 152g of Jiangxiang, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, and the extraction time is 180min to obtain a supercritical extract, which is added with starch and 70% ethanol to make granules, dried and made into 650g.

Embodiment 3

[0020] Take 456g of Salvia miltiorrhiza, 228g of red peony, 228g of Chuanxiong, 228g of safflower, and 152g of Jiangxiang, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug min, and the extraction time is 160min to obtain a supercritical extract, add starch, 70% ethanol to make granules, and dry to make 650g.

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Abstract

The invention provides a preparation method of a purified coronary disease particle. 456 g of red sage root, 228 g of radix paeoniae rubrathe, 228 g of ligusticum wallichii, 228 g of safflower and 152 g of lignum dalbergiae odoriferae are used as bulk pharmaceutical chemicals. The purified coronary disease particle is prepared by supercritical extraction, thus improving the content and reducing the medicine taking amount. The invention also provides an application of the purified coronary disease particle in preparation of medicines inhibiting proliferation of rhabdomyosarcoma A-204 cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of refined Guanxin Granules. Background technique [0002] Refined Guanxin Granules are recorded in the Pharmacopoeia. The prescription is 456g of Danshen, 228g of Chishao, 228g of Chuanxiong, 228g of Safflower, and 152g of Jiangxiang. hours, 1.5 hours for the second time, 1 hour for the third time, filter, and combine the filtrates; add appropriate amount of water to safflower, soak twice at 80°C, 2 hours for the first time, 1 hour for the second time, filter, and combine with the above filtrate Combine, concentrate to a thick paste, dry at 80°C, crush into fine powder, add appropriate amount of sucrose and dextrin, mix well, make granules, dry, and make 1300g, that is, can promote qi and blood circulation, remove blood stasis and unblock the veins . For qi stagnation and blood stasis, chest obstruction, he...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/16A61P9/10A61P35/00A61P21/00
Inventor 不公告发明人
Owner 王玮玮
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