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Lubrication composition having certain viscosity and used for preventing birth trauma

A lubricating composition and the technology of the composition, applied in the field of medicine and health, can solve the problems of not obvious effect of preventing birth canal damage, difficult to ensure aseptic conditions, limited lubricating effect, etc.

Active Publication Date: 2014-01-29
北京亿灵医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, the existing auxiliary lubricating substances peanut oil and glycerin have limited lubricating effect, and the effect of preventing birth canal damage is not obvious; Infection hazards for pregnant women during childbirth
The lateral incision method directly brings damage to the parturient, and has the risk of further vaginal tearing and infection

Method used

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  • Lubrication composition having certain viscosity and used for preventing birth trauma
  • Lubrication composition having certain viscosity and used for preventing birth trauma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] components Prescription amount (g) Hydroxyethyl Cellulose 250M(g) 32 Sodium chloride (g) 4.95 1,2-Propanediol (g) 150 Purified water (g) 813.05 Co-made 1000g

[0035] Preparation: Take 700ml of water, stir, slowly add 32.0g of hydroxyethyl cellulose, stir and swell for 3 hours; take 113ml of water, add 4.95g of sodium chloride, dissolve, add to the above solution, stir for 30min; take 150g of propylene glycol, add to the above solution, Stir for 1 hour, and let it stand overnight; package the prepared preparation into a disposable injection, measure 20ml / unit, sterilize at 121°C for 15 minutes, and cool down.

[0036] The prepared lubricating composition preparation is colorless and transparent in appearance, has no irritating peculiar smell, and is gel-like. The measured pH value is 6.45, and the viscosity value (3 rpm) is 90Pa.s.

Embodiment 2

[0038] components Prescription amount (g) carbomer 13 Sodium chloride 4.95 sodium hydroxide 4 Propylene Glycol 150 water 828.05 Co-made 1000g

[0039] Preparation: Take 700ml of water, stir, slowly add 13g of carbomer, stir and swell for 3 hours; take 128ml of water, add 4.95g of sodium chloride and 4g of sodium hydroxide, dissolve, and add to the above solution. Stir for 30min; take 150g of propylene glycol and add it to the above solution. Stir for 1h. Let stand overnight. The prepared preparation is packaged into a disposable injection, 20ml / unit, sterilized at 121°C for 15min, and cooled.

[0040] The prepared lubricating composition preparation is colorless and transparent in appearance, has no irritating peculiar smell, and is gel-like. The measured pH value is 6.37, and the viscosity value (3 rpm) is 82Pa.s.

Embodiment 3

[0042] components Prescription amount (g) pectin 80 Sodium chloride 4.95 sodium hydroxide 9.6 Propylene Glycol 150 water 755.45 Co-made 1000

[0043] Preparation: Take 756ml of water, add 4.95g of sodium chloride and 9.6g of sodium hydroxide, stir and dissolve; slowly add 80g of pectin, stir and swell for 3h; take 150g of propylene glycol, add to the above solution, stir for 1h, and let stand overnight; A good preparation is packaged into a disposable injection, 20ml / unit metered, and ethylene oxide sterilized.

[0044] The measured pH value of the prepared lubricating composition preparation was 5.47, and the viscosity value (3 revolutions / minute) was 95 Pa.s.

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Abstract

The invention provides a lubrication composition having certain viscosity and a preparation thereof, wherein the lubrication composition having certain viscosity is used for preventing injury of birth canal during spontaneous labor, for example, laceration of perineum. The lubrication composition provided by the invention is mainly applied to the second stage of labor namely the stage from the opening of the uterine orifice to delivery of baby; the viscosity range of the lubrication composition is from 0.001 to 200 Pa.s, mainly from 35 to 150 Pa.s, and more specifically from 60 to 90 Pa.s in which the effect of the lubrication composition is better. The lubrication composition provided by the invention is stored and applied in the form of liquid, and is a sterile preparation. The lubrication composition provided by the invention is capable of effectively reducing the injuries of a puerpera such as laceration of perineum in the process of assisting delivery; as a result, the perineum complete rate is increased to 90% or higher; the lubrication composition is obvious in effect.

Description

technical field [0001] The invention relates to the field of medicine and hygiene, in particular to a lubricating composition with a certain viscosity for preventing childbirth injuries. Background technique [0002] Maternal childbirth is accompanied by pain and injury, especially natural childbirth may cause a certain degree of harm to the mother and baby. Childbirth injuries include mechanical injuries, i.e. birth injuries, as well as ischemic and hypoxic injuries, perineal tear, cervical laceration, uterine rupture, birth canal hematoma, urinary system injury, postpartum hemorrhage and hemorrhagic shock, etc. [0003] The most common clinical childbirth injury is mainly perineal tear, which brings huge unspeakable concealment and inconvenience to women, and seriously affects the physical and mental health and quality of life of patients. The improvement of the quality of life of modern puerpera also makes the fetus tend to increase in weight in the mother's womb, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/16
Inventor 关屹闫冬高晓峰
Owner 北京亿灵医药科技发展有限公司
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