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A cyclic synthetic polypeptide c and its antibacterial and antiviral applications

A synthetic peptide, cyclic technology, applied in the direction of antiviral agents, antibacterial drugs, medical preparations containing active ingredients, etc., can solve the problems of marine aquaculture animals that are difficult to fundamentally control, hinder the healthy development of aquaculture production, etc. question

Active Publication Date: 2016-01-20
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Shrimp farming occupies an important position in my country's aquaculture industry. In recent years, the disease problems in the shrimp farming process have seriously hindered the healthy development of its farming production. The abuse of antibiotics and the deterioration of the environment have made it difficult for marine animals to suffer from diseases. fundamentally under control

Method used

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  • A cyclic synthetic polypeptide c and its antibacterial and antiviral applications
  • A cyclic synthetic polypeptide c and its antibacterial and antiviral applications
  • A cyclic synthetic polypeptide c and its antibacterial and antiviral applications

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0022] The present invention is described in further detail below in conjunction with embodiment.

[0023] A chemically synthesized prawn cyclic polypeptide C with obvious antibacterial and antiviral activities, its sequence and source sequence information are as follows:

[0024] (1) Information of SEQ ID No.1

[0025] (a) Sequential features

[0026] * Length: 24 amino acids

[0027] *Type: amino acid

[0028] * Chain type: single chain

[0029] *Topology: ring, disulfide bond formed between two cysteines

[0030] * Spatial structure: has 1) figure 1 Skeleton structure shown: Two cysteines are connected by disulfide bonds to form a ring structure, where the disulfide bonds are shown in darker black, and the C skeleton and other atoms are shown in gray; and 2) figure 2 The spatial structure shown: the polypeptide sequence forms two connected β-sheet structures.

[0031] (b) Molecule type: protein

[0032] Sequence description: SEQIDNo.1

[0033] Ac-Qc(CTYSVTPTVKSFEL...

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Abstract

The invention relates to a cyclic synthetic peptide C, and antibacterial and antiviral application thereof. The cyclic synthetic peptide C related to the invention has an amino acid sequence and structural characteristics shown in SEQ ID No.1 in a sequence list; the cyclic synthetic peptide C is derived from an LPS binding structure domain of a fenneropenaeus merguiensis anti-lipopolysaccharide factor FcALF1 shown in SEQ ID No.2 in the sequence list. The cyclic synthetic peptide C is verified to have a certain inhibiting effect on growth of a gram-positive bacterium and a gram-negative bacterium, and a strong inhibiting effect on multiplication of a virus by carrying out biological functional verification on the cyclic synthetic peptide C related to the invention.

Description

technical field [0001] The present invention relates to a cyclic synthetic polypeptide C and its antibacterial and antiviral applications, in particular to a synthetic cyclic polypeptide derived from the lipopolysaccharide (LPS) binding domain of the Chinese prawn anti-lipopolysaccharide factor FcALF1 and Its antibacterial and antiviral applications. Background technique [0002] Shrimp farming occupies an important position in my country's aquaculture industry. In recent years, the disease problems in the shrimp farming process have seriously hindered the healthy development of its farming production. The abuse of antibiotics and the deterioration of the environment have made it difficult for marine animals to suffer from diseases. fundamentally under control. [0003] Antimicrobial peptides (proteins) are considered to be important effector molecules for fish, shrimp, shellfish, etc. to defend against infection by exogenous pathogens such as bacteria and viruses, and play ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/435A61K38/17A61P31/04A61P31/20
Inventor 李富花李诗豪郭书悦相建海
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI