Use of cytokine levels in intravenous immunoglobulin treatment of alzheimer's disease
A technology for Alzheimer's disease and cytokines, applied in the field of cytokine levels in the intravenous immunoglobulin therapy of Alzheimer's disease, which can solve the problems that there is no known therapy for Alzheimer's disease
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[0065] Example 1: Changes in plasma cytokines following intravenous immunoglobulin (IVIG) treatment in patients with Alzheimer's disease (AD)
[0066] Objectives: (1) To explore changes in plasma cytokine levels associated with administration of IVIG to AD patients; (2) To compare cytokine changes with placebo-controlled, randomized II of Gammagard IVIG for mild to moderate AD associated with the clinical outcomes of the Phase 1 study.
[0067] Methods: Plasma samples were drawn from all individuals in a phase II study of IVIG for mild to moderate AD. At baseline and 6 months, plasma samples were obtained by phlebotomy before infusion. The study was performed after informed consent.
[0068] Blood draws were obtained before the first and last infusion to avoid potential confounding effects of reported short-term cytokine fluxes following IVIG infusion.
[0069] Levels of selected cytokines and chemokines were analyzed using assays optimized for the Luminex platform. Approp...
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