Preparation method of bacteriostatic herba elsholtziae oil

Abstract

The invention relates to a preparation method for bacteriostatic herba elsholtziae oil. The preparation method comprises the following steps: (1) water vapour distillation: weighing 1 kilogram of herba elsholtziae, smashing, pouring into a distilling flash, adding water of which the weight is 10 times the weight of herba elsholtziae, installing a volatile oil extractor, carrying out steam distillation for 6 hours, pouring water-containing volatile oil into a separating from the volatile oil extractor, separating out a part of water-containing volatile oil, freezing at 10 DEG C below zero overnight in a refrigerator, removing ice to get the light yellow volatile oil, wherein the yield is 1.8%; and (2) weighing 1 kilogram of herba elsholtziae, smashing, putting the smashed herba elsholtziae in a 5L supercritical extraction kettle, starting the extraction kettle and a separating kettle heating device, starting a compression pump when a set temperature is reached, keeping cyclically extracting for 3h under the condition that the pressure in the extraction kettle is 20.0 MPa, the temperature in the extraction kettle is 50 DEG C, the flow velocity of CO2 in the extraction kettle is 40kg / h, the pressure and temperature of the separation kettle is 10.0 MPa and 30 DEG C respectively, thus obtaining a yellow oily substance which has special fragrance, wherein the extraction yield is 3%.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of bacteriostatic fenugreek oil. Background technique

[0002] At present, the continuous rise of drug resistance due to the abuse of antibiotics has become one of the problems of common concern all over the world. In particular, the drug resistance rate of Staphylococcus aureus has reached 90%. At the same time, the intestinal flora disorder caused by antibiotics also aggravates the primary infection. It is of practical significance to find anti-infective drugs from natural products. Elsholtzia densa Benth. is a plant of the genus Elsholtzia of the Lamiaceae, distributed in Yunnan, Hebei, Shanxi, Shaanxi, Gansu, Qinghai, Sichuan, Tibet, Xinjiang and other provinces and regions. It is used as a substitute for fenugreek in Tibet, and it can also be used externally for skin diseases.

[0003] At present, there are reports on the components of t...