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A kind of borneol brucei oil nanoemulsion and preparation method thereof

A technology of javanica javanica oil and nanoemulsion, which is applied in the fields of pharmaceutical formula, emulsion delivery, and medical preparations containing active ingredients, etc. It can solve the problems of low drug concentration of javanica javanica oil entering the brain, clinical application limitations, demulsification and stratification, etc. problems, to achieve strong anti-tumor effect, good stability, uniform particle size distribution

Inactive Publication Date: 2016-03-09
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main marketed preparation is javanica javanica oil emulsion for injection, but because the emulsion is a heterogeneous dynamically unstable dispersion system with a large particle size, it is prone to demulsification and stratification, and due to the blood-brain barrier, javanica javanica oil enters the brain drug The concentration is low, so its clinical application is limited

Method used

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  • A kind of borneol brucei oil nanoemulsion and preparation method thereof
  • A kind of borneol brucei oil nanoemulsion and preparation method thereof
  • A kind of borneol brucei oil nanoemulsion and preparation method thereof

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Embodiment 1

[0034] 1 material

[0035] 1.1 Instrument

[0036] Shimadzu GC-2010 Gas Chromatograph (Shimadzu Corporation, Japan), JEM-1200EX Transmission Electron Microscope (Hitachi Corporation, Japan), 380ZLS Laser Particle Size Analyzer (Nicomp Corporation, USA), Stereotaxic Instrument (Narishige Corporation, Japan), Bio-RAD680 Microplate reader (Bio-RAD, USA), ZEISSAxiovert200 fluorescence inverted microscope (CarlZeiss, Germany), ThermoScientificFormaII water jacket CO 2 Incubator (Thermo Company, USA), CP225D electronic balance (Beijing Sartorius Instrument System Co., Ltd.), KQ5200DE CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.), HZ-92125 constant temperature oscillator (Jiangsu Taicang Science and Education Equipment Factory ), DF-101S heat-collecting constant temperature stirrer (Gongyi Yingyu Yuhua Instrument Factory), HJ-6B multi-head speed-measuring heating mixer (Jintan Jinwei Experimental Instrument Factory), TGL-16B high-speed desktop centrifuge (Shanghai...

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Abstract

The invention provides borneol and oleum fructus bruceae nanoemulsion and a preparation method thereof. The borneol and oleum fructus bruceae nanoemulsion is mainly prepared by the phase inversion method through the following raw materials in parts by mass: 30 to 40 parts of isopropyl myristate, 30 to 40 parts of oleum fructus bruceae containing 0.5 to 2.0% (w / w) of borneol, 15 to 20 parts of emulsifier CremopherRH40, and 10 to 15 parts of co-emulsifier. According to the borneol and oleum fructus bruceae nanoemulsion capable of passing through a blood brain barrier and the preparation method thereof, the prepared borneol and oleum fructus bruceae nanoemulsion is uniform in size distribution, relatively high in oleic acid content and high in stability, shows relatively high effect on inhibiting rat glioma, provides a reference for developing an oleum fructus bruceae dosage form for treating brain glioma, as well as provides experiment basis for the study on a novel nanoemulsion delivery system.

Description

technical field [0001] The invention relates to a nanoemulsion of borneol javanica oil and a preparation method thereof. Background technique [0002] Brucea javanica oil (Brucea javanica oil) is a fatty oil extracted from the dried mature fruit of Brucea javanica. The content reaches 60%. Pharmacological studies have found that javanica javanica oil has many advantages such as low toxicity, high efficiency, and broad anticancer spectrum. It is used to treat tumors such as lung cancer, liver cancer, gastric cancer, and breast cancer. It can also be used to inhibit glioma and reduce intracranial pressure. Show good application prospects. The main marketed preparation is javanica javanica oil emulsion for injection, but because the emulsion is a heterogeneous dynamically unstable dispersion system with a large particle size, it is prone to demulsification and stratification, and due to the blood-brain barrier, javanica javanica oil enters the brain drug The concentration is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K9/107A61K47/10A61P35/00A61P25/00
Inventor 李范珠王国伟徐骏军李颖芳魏颖慧郭曼曼徐秀玲
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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