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A kind of CO2 supercritical extraction method of active ingredient in lettuce

An effective ingredient and a technology of radicchio, applied in the field of radicchio extraction, can solve the problem that the yield of flavonoids and triterpenoids cannot be guaranteed at the same time, the content of insoluble impurities in supercritical fluid is high, and the active ingredients of medicinal materials are easily destroyed. and other problems, to achieve the effect of good flow and transfer performance, increased extraction capacity, and strong dissolving capacity

Active Publication Date: 2016-02-03
山东世博金都药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, water extraction or alcohol extraction is traditionally used to extract the active ingredients in Chinese lettuce. The extraction process has high temperature, which easily destroys the active ingredients in the medicinal materials, consumes a lot of water and ethanol and other solvents, and consumes a lot of energy. and other disadvantages, it is urgent to adopt advanced extraction technology to extract its biologically active components
[0004] The prior art has not yet involved the technology of supercritical extraction of lettuce, and the technical difficulty is that the lettuce contains quercetin, isorhamnetin, koyrin, acacetin, apigenin and teretin. and other flavonoids; it also contains triterpenoids such as oleanolic acid and ursolic acid; its volatile oil contains acids, esters, and alcohols
In the prior art, when the lettuce is extracted by supercritical extraction technology, because the extraction conditions are not easy to grasp, it is impossible to ensure that flavonoids and triterpenoids can obtain higher yields at the same time.
In the prior art, extracting lettuce juice is used as the solute of the supercritical fluid, which easily causes the content of insoluble impurities in the supercritical fluid to be too high, which affects the extraction yield; the residue left by squeezing and filtering lettuce juice still contains a relatively high content flavonoids and triterpenoids, resulting in waste of raw materials

Method used

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  • A kind of CO2 supercritical extraction method of active ingredient in lettuce

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] a) Take 100g of Chinese lettuce medicinal materials and crush them with a crusher, and pass through a 20-mesh sieve;

[0022] b) Soak the broken lettuce in an ethanol-water solution for 2 hours, and the concentration of ethanol in the ethanol-water solution is 30% by volume;

[0023] c) Put the soaked lettuce into the supercritical extraction equipment for CO 2 Supercritical extraction, extraction kettle temperature 60°C, extraction kettle pressure 15Mpa, separation kettle I temperature 65℃, separation kettle I pressure 8Mpa, separation kettle II temperature 35℃, separation kettle II pressure 6Mpa, add 100ml of 30% ethanol as entrainer, The extraction time is 6 hours;

[0024] d) The extracts obtained from the two separation tanks were combined and concentrated at 50° C. under normal pressure for 6 hours to obtain the lettuce extract.

Embodiment 2

[0026] a) Take 100g of Chinese lettuce medicinal materials and crush them with a crusher, and pass through a 10-mesh sieve;

[0027] b) Soak the broken lettuce in an ethanol-water solution for 1 hour, and the concentration of ethanol in the ethanol-water solution is 40% by volume;

[0028] c) Put the soaked lettuce into the supercritical extraction equipment for CO 2 Supercritical extraction, extraction kettle temperature 55°C, extraction kettle pressure 18Mpa, separation kettle I temperature 55°C, separation kettle I pressure 10Mpa, separation kettle II temperature 39°C, separation kettle II pressure 7Mpa, add 100ml of 30% ethanol as entrainer, The extraction time is 6 hours;

[0029] d) The extracts obtained from the separation tanks I and II were combined, concentrated at 55° C. under reduced pressure of 0.02 Mpa for 5 hours, and the lettuce extract was obtained.

Embodiment 3

[0031] a) Take 100g of Chinese lettuce medicinal materials and crush them with a crusher, and pass through a 10-mesh sieve;

[0032] b) Soak the broken lettuce in an ethanol-water solution for 8 hours, and the concentration of ethanol in the ethanol-water solution is 60% by volume;

[0033] c) Put the soaked lettuce into the supercritical extraction equipment for CO 2 Supercritical extraction, extraction kettle temperature 40°C, extraction kettle pressure 25Mpa, separation kettle I temperature 40°C, separation kettle I pressure 8Mpa, separation kettle II temperature 36°C, separation kettle II pressure 5Mpa, add 100ml of 90% ethanol as entrainer, The extraction time is 1 hour;

[0034] d) Combine the extracts obtained from the separation tanks I and II, and concentrate at 40° C. under normal pressure for 7 hours to obtain the lettuce extract.

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Abstract

The invention discloses a method for CO2 supercritical extraction of effective components in Chickweed, which belongs to the technical field of Chickpea extraction. In the present invention, the lettuce is first crushed through a 10-20 mesh sieve, then soaked in ethanol-water solution, and CO2 supercritical extraction is used in double separation kettles, the temperature of the extraction kettle is set at 35-60°C, the pressure of the extraction kettle is 12-30Mpa, and the separation The temperature of kettle I is 40~65℃, the pressure of separation kettle I is 8~12Mpa, the temperature of separation kettle II is 35~40℃, the pressure of separation kettle II is 5~8Mpa, add 10%~95% ethanol as entrainer, and the extraction time is 2~6 Hours; after concentration to obtain lettuce extract. The method of the invention can maintain the total flavonoid content in the lettuce extract at a relatively high value, which can reach more than 3.9 mg / g.

Description

Technical field [0001] CO of an active ingredient in a kind of amaranth 2 The supercritical extraction method belongs to the field of amaranth extraction technology. Background technique [0002] Aya vegetables are chrysanthemum plants, also known as bitter amaranth.Aya vegetables have the effects of clearing heat and detoxifying, cooling blood and dampness, swelling, pus, removing stasis and pain, and supplementing deficiency and relieving cough.It has a good role in preventing and treating anemia, maintaining normal physiological activities of the human body, and promoting growth and development and heat -elimination.The concentrated ethanol extraction solution of amaranth water is inhibited for acute lymphocytic leukemia, acute and chronic granulocytic leukemia.The cold taste is bitter, and it has the effects of anti -heat and detoxification, cooling blood, dampness, swelling, pus, removing stasis, pain, and relieving cough and relieving cough. [0003] In existing technologie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28
Inventor 闫敬武杜成德郗光建
Owner 山东世博金都药业有限公司