Nano ibuprofen dry powder, tablets and preparation method thereof

A nano-powder and tablet technology, which is applied in anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc., can solve the problems of ibuprofen's poor water solubility, oral absorption and low bioavailability, and achieve improved curative effect and high dissolution rate , the effect of high drug loading

Inactive Publication Date: 2014-03-26
HUBEI UNIVERSITY OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the deficiencies in the prior art, in order to solve the problems of poor water solubility of ibuprofen, oral absorption and low bioavailability, to provide a kind of nano ibuprofen spray dry powder with good dispersion degree, good absorption and good stability , and the method of preparing dry powder into tablets at the same time

Method used

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  • Nano ibuprofen dry powder, tablets and preparation method thereof
  • Nano ibuprofen dry powder, tablets and preparation method thereof
  • Nano ibuprofen dry powder, tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A: Weigh 10g of ibuprofen and dissolve it in 50ml of ethanol;

[0030] B: Weigh 10g of polyvinylpyrrolidone, 5g of polyethylene glycol, 100g of hydroxypropyl methylcellulose, 3g of poloxamer, 3g of oleic acid and 3g of sodium oleate, and dissolve them in 500ml of distilled water;

[0031] C: slowly drop the ethanol solution of ibuprofen into the above-mentioned 500ml mixed solution; high-speed stirring reaction at room temperature to obtain ibuprofen nano-suspension;

[0032] D: The dry powder is obtained by spray drying with a spray dryer. Set the inlet temperature to 120°C, the outlet temperature to 80°C, the feed flow rate to 5ml / min, and the compressed air pressure to 0.6Mpa;

[0033] E: Add appropriate amount of excipients to the dry powder and press it into tablets. Take 1g of the ibuprofen nano-powder obtained in step D, mix with 0.6g of starch, 0.18g of micropowder silica gel, and 0.1g of CMS-Na, add 1.2g of 15% starch slurry to make a soft material, pass throu...

Embodiment 2

[0035] A: Weigh 10g of ibuprofen and dissolve it in 50ml of ethanol;

[0036] B: Weigh 10g of polyvinylpyrrolidone, 10g of polyethylene glycol, 90g of hydroxypropyl methylcellulose, 5g of poloxamer and 5g of sodium oleate, and dissolve them in 500ml of distilled water;

[0037] C: slowly drop the ethanol solution of ibuprofen into the above-mentioned 500ml mixed solution; high-speed stirring reaction at room temperature to obtain ibuprofen nano-suspension;

[0038] D: The dry powder is obtained by spray drying with a spray dryer, the inlet temperature is 140°C, the outlet temperature is 80°C, the feed flow rate is 10ml / min, and the compressed air pressure is 0.4Mpa;

[0039] E: Add appropriate amount of excipients to the dry powder and press it into tablets. Take 1g of the ibuprofen nano-powder obtained in step D, mix with 0.6g of starch, 0.18g of micropowder silica gel, and 0.1g of CMS-Na, add 1.2g of 15% starch slurry to make a soft material, pass through a 16-mesh sieve to...

Embodiment 3

[0041] A: Weigh 10g of ibuprofen and dissolve it in 50ml of ethanol;

[0042] B: Weigh 20g of polyvinylpyrrolidone, 10g of polyethylene glycol, 80g of hydroxypropyl methylcellulose, 5g of poloxamer, 3g of lecithin and 3g of sodium oleate, and dissolve them in 500ml of distilled water;

[0043] C: slowly drop the ethanol solution of ibuprofen into the above-mentioned 500ml mixed solution; high-speed stirring reaction at room temperature to obtain ibuprofen nano-suspension;

[0044] D: The dry powder is obtained by spray drying with a spray dryer. Set the inlet temperature to 120°C, the outlet temperature to 80°C, the feed flow rate to 10ml / min, and the compressed air pressure to 0.6Mpa.

[0045] E: Add appropriate amount of excipients to the dry powder and press it into tablets. Take 1g of the ibuprofen nano-powder obtained in step D, mix with 0.6g of starch, 0.18g of micropowder silica gel, and 0.1g of CMS-Na, add 1.2g of 15% starch slurry to make a soft material, pass throug...

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Abstract

The invention relates to a preparation method of nano ibuprofen dry powder and tablets thereof. The preparation method comprises the following steps of: firstly dissolving ibuprofen in an organic solvent, then dissolving multiple pharmaceutical adjuvants into water, carrying out spraying and drying on slurry formed by mixing the two types of solution under proper conditions at room temperature, successfully preparing nano ibuprofen powder with the water-soluble particle diameter being 20-200nm, and mixing and pressing the dry powder and proper adjuvants into the tablets. The tablets can be dispersed in water quickly, and the dissolving-out rate is obviously higher than that of a tablet mixed and pressed by crude drugs and same adjuvants. All the adjuvants in the invention conform to pharmacopeia standards, is biodegradable and is good in biocompatibility. The preparation method is simple in process, safe in operation, low in cost and easy in realizing industrial production of nano ibuprofen drugs.

Description

technical field [0001] The present invention relates to a kind of preparation method of nano ibuprofen dry powder and dry powder tablet thereof technical background [0002] Ibuprofen (Ibuprofen), chemical name 2-(4-isobutylphenyl) propionic acid, its structural formula is as follows [0003] [0004] Ibuprofen is a high-efficiency non-steroidal anti-inflammatory drug with strong antipyretic, analgesic and anti-inflammatory effects. It can be used clinically for the treatment of various inflammations and diseases. In use, they are capsules, granules, tablets, suspensions, suppositories, ointments and syrups. The most commonly used method clinically is oral administration. But ibuprofen is water insoluble medicine, and common ibuprofen tablet medicine bioavailability is low. [0005] For poorly water-soluble drugs, the dissolution process is the key factor restricting their bioavailability. According to the Ostwald Freundrich equation, the drug dissolution rate is inve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/192A61K47/38A61K47/34A61K47/32A61K47/24A61K47/12A61K47/28A61P29/00
Inventor 陈绚丽黎光强桂裕亮
Owner HUBEI UNIVERSITY OF MEDICINE
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