Common alstonia leaf extractum and extract as well as preparation methods thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of the leaves and extracts of the lampstand, which is applied in the field of medicine, can solve the problem of low content of active ingredients, and achieve comprehensive curative effect and good anti-inflammatory effect
Active Publication Date: 2014-03-26
YUNNAN PHYTOPHARML
View PDF3 Cites 6 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0005] Although the extract of the leaves obtained by water extraction and alcohol precipitation also contains active ingredients such as flavonoids, terpenoids, and alkaloids, due to the limitation of the process, the contents of active ingredients such as flavonoids, terpenoids, and alkaloids are all low
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0038]Take 7kg of phoenix leaf medicinal material, add 80% (volume concentration, the same below) ethanol solution that is 8 times the weight of the medicinal material, extract 2 times, each time for 2 hours, combine the extracts, filter, concentrate to 60% of the weight of the raw medicinal material, add extraction 20 times the weight of the concentrated liquid, then add hydrochloric acid to adjust the pH to 3, stir for 2 hours, let stand for 36 hours, filter, add sodium hydroxide to adjust the pH to pH 5, and concentrate the filtrate to a lampstand with a relative density of 1.2g / ml Leaf extract.
Embodiment 2
[0040] Take 7kg of the phoenix leaf medicinal material, add 80% ethanol solution 8 times the weight of the medicinal material to extract twice, each time for 2 hours, combine the extracts, filter, concentrate to 60% of the weight of the raw medicinal material, add 20 times the weight of the concentrated extract water, then add hydrochloric acid to adjust the pH to 3, stir for 2 hours, let stand for 36 hours, filter, add sodium hydroxide to adjust the pH to pH 5, when the filtrate is concentrated to half, add chloroform to extract 3 times, and recover the chloroform extract under reduced pressure , to obtain the lamprey leaf extract.
Embodiment 3
[0042] Take 7kg of the medicinal material of the lampstand leaf, add 60% ethanol solution 6 times the weight of the medicinal material to extract once, 1 hour each time, combine the extracts, filter, concentrate to 20% of the weight of the raw medicinal material, add 1 times the weight of the concentrated extract Water, then add sulfuric acid to adjust the pH to 1.8, stir for 0.5 hours, let stand for 12 hours, filter, add sodium carbonate to adjust the pH to pH 3, and concentrate the filtrate to the extract of the leaves of the lampstand with a relative density of 1.0g / ml.
[0043] Add 120 g of sorbitol, 2 g of sodium benzoate, 0.2 g of ethylparaben, 0.4 g of aspartame, and distilled water to the extract of the lampstand leaves, mix them with distilled water, add water to 900 ml, adjust the pH with 10% NaOH solution, and constant volume to 1000ml, filtered, filled, sterilized, each filled with 10ml, to obtain oral liquid.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses common alstonia leaf extractum and extract as well as preparation methods thereof. The preparation method of the common alstonia leaf extractum comprises the following steps: adding 60%-95% v/v of an ethanol solution with the weight being 6-12 times that of common alstonia leaves, performing reflux extraction for 1-3 times with each for 1-3 hours, combining extracting solutions, filtering, concentrating until the weight of the solution accounts for 20%-60% of that of the unprocessed common alstonia leaves, adding water with the weight being 1-20 times that of the concentrated extracting solution, adding a reagent for adjusting the pH value to be 1.8-8, stirring for 0.5-5 hours, standing for 12-72 hours, filtering, adding the reagent for adjusting the pH value to be 3-8.5, and concentrating a filter liquor until the relative density is 1.0-1.35 g/ml to obtain the common alstonia leaf extract. The preparation method of the common alstonia leaf extract comprises the following steps: adding one or more of chloroform, ethyl acetate and n-butyl alcohol into the common alstonia leaf filter liquor with the pH value of 3-8.5, extracting for 1-4 times, performing reduced pressure concentration, and recovering a solvent to obtain the common alstonia leaf extract. The content of total alkaloids, total triterpenes and total flavonoids in the extractum and the extract is higher, and the treatment effects of the extractum and the extract in easing pain, diminishing inflammation, eliminating phlegm, relieving cough, preventing asthma and the like are superior to those of drugs prepared by a conventional common alstonia leaf water-extraction and alcohol-precipitation process.
Description
technical field [0001] The invention relates to the technical field of medicines, in particular to a lamprey leaf extract and extract with high content of active ingredients and a preparation method thereof. Background technique [0002] The lampstand leaf is derived from the plant lampstand tree of the family Apocynaceae Alstonia scholars (L.) R. Br., its nature and flavor are sweet, light, flat, and has the effects of clearing heat and detoxification, reducing swelling and pain, relieving asthma and relieving cough, stopping malaria, sweating, and invigorating the stomach. The lampstand tree is mainly distributed in the south and west of Guangxi and southern Yunnan in my country, and it is also distributed in subtropical regions such as Myanmar, Thailand, and Vietnam. In recent years, with the gradual development of research on its chemical composition and pharmacological activity, it has been found that its active ingredients are rich in anti-tumor, anti-inflammatory, ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more