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Common alstonia leaf extractum and extract as well as preparation methods thereof

A technology of the leaves and extracts of the lampstand, which is applied in the field of medicine, can solve the problem of low content of active ingredients, and achieve comprehensive curative effect and good anti-inflammatory effect

Active Publication Date: 2014-03-26
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the extract of the leaves obtained by water extraction and alcohol precipitation also contains active ingredients such as flavonoids, terpenoids, and alkaloids, due to the limitation of the process, the contents of active ingredients such as flavonoids, terpenoids, and alkaloids are all low

Method used

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  • Common alstonia leaf extractum and extract as well as preparation methods thereof
  • Common alstonia leaf extractum and extract as well as preparation methods thereof
  • Common alstonia leaf extractum and extract as well as preparation methods thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038]Take 7kg of phoenix leaf medicinal material, add 80% (volume concentration, the same below) ethanol solution that is 8 times the weight of the medicinal material, extract 2 times, each time for 2 hours, combine the extracts, filter, concentrate to 60% of the weight of the raw medicinal material, add extraction 20 times the weight of the concentrated liquid, then add hydrochloric acid to adjust the pH to 3, stir for 2 hours, let stand for 36 hours, filter, add sodium hydroxide to adjust the pH to pH 5, and concentrate the filtrate to a lampstand with a relative density of 1.2g / ml Leaf extract.

Embodiment 2

[0040] Take 7kg of the phoenix leaf medicinal material, add 80% ethanol solution 8 times the weight of the medicinal material to extract twice, each time for 2 hours, combine the extracts, filter, concentrate to 60% of the weight of the raw medicinal material, add 20 times the weight of the concentrated extract water, then add hydrochloric acid to adjust the pH to 3, stir for 2 hours, let stand for 36 hours, filter, add sodium hydroxide to adjust the pH to pH 5, when the filtrate is concentrated to half, add chloroform to extract 3 times, and recover the chloroform extract under reduced pressure , to obtain the lamprey leaf extract.

Embodiment 3

[0042] Take 7kg of the medicinal material of the lampstand leaf, add 60% ethanol solution 6 times the weight of the medicinal material to extract once, 1 hour each time, combine the extracts, filter, concentrate to 20% of the weight of the raw medicinal material, add 1 times the weight of the concentrated extract Water, then add sulfuric acid to adjust the pH to 1.8, stir for 0.5 hours, let stand for 12 hours, filter, add sodium carbonate to adjust the pH to pH 3, and concentrate the filtrate to the extract of the leaves of the lampstand with a relative density of 1.0g / ml.

[0043] Add 120 g of sorbitol, 2 g of sodium benzoate, 0.2 g of ethylparaben, 0.4 g of aspartame, and distilled water to the extract of the lampstand leaves, mix them with distilled water, add water to 900 ml, adjust the pH with 10% NaOH solution, and constant volume to 1000ml, filtered, filled, sterilized, each filled with 10ml, to obtain oral liquid.

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Abstract

The invention discloses common alstonia leaf extractum and extract as well as preparation methods thereof. The preparation method of the common alstonia leaf extractum comprises the following steps: adding 60%-95% v / v of an ethanol solution with the weight being 6-12 times that of common alstonia leaves, performing reflux extraction for 1-3 times with each for 1-3 hours, combining extracting solutions, filtering, concentrating until the weight of the solution accounts for 20%-60% of that of the unprocessed common alstonia leaves, adding water with the weight being 1-20 times that of the concentrated extracting solution, adding a reagent for adjusting the pH value to be 1.8-8, stirring for 0.5-5 hours, standing for 12-72 hours, filtering, adding the reagent for adjusting the pH value to be 3-8.5, and concentrating a filter liquor until the relative density is 1.0-1.35 g / ml to obtain the common alstonia leaf extract. The preparation method of the common alstonia leaf extract comprises the following steps: adding one or more of chloroform, ethyl acetate and n-butyl alcohol into the common alstonia leaf filter liquor with the pH value of 3-8.5, extracting for 1-4 times, performing reduced pressure concentration, and recovering a solvent to obtain the common alstonia leaf extract. The content of total alkaloids, total triterpenes and total flavonoids in the extractum and the extract is higher, and the treatment effects of the extractum and the extract in easing pain, diminishing inflammation, eliminating phlegm, relieving cough, preventing asthma and the like are superior to those of drugs prepared by a conventional common alstonia leaf water-extraction and alcohol-precipitation process.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a lamprey leaf extract and extract with high content of active ingredients and a preparation method thereof. Background technique [0002] The lampstand leaf is derived from the plant lampstand tree of the family Apocynaceae Alstonia scholars (L.) R. Br., its nature and flavor are sweet, light, flat, and has the effects of clearing heat and detoxification, reducing swelling and pain, relieving asthma and relieving cough, stopping malaria, sweating, and invigorating the stomach. The lampstand tree is mainly distributed in the south and west of Guangxi and southern Yunnan in my country, and it is also distributed in subtropical regions such as Myanmar, Thailand, and Vietnam. In recent years, with the gradual development of research on its chemical composition and pharmacological activity, it has been found that its active ingredients are rich in anti-tumor, anti-inflammatory, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/24A61P11/00A61P29/00A61P11/14A61P11/10A61P11/06A61K127/00
Inventor 李俊梅艳刘兴娟张建敏杨丽芬
Owner YUNNAN PHYTOPHARML
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