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Anti-influenza medicine and preparation method thereof

A technology for influenza and medicine, applied in the field of medicine for cold and its preparation, can solve the problems of large dosage, inconvenience to carry, and difficulty of Western medicine to play an ideal role, and achieves the effect of prolonging the survival days and reducing the mortality rate.

Active Publication Date: 2016-04-13
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides an anti-influenza drug and its preparation method, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the problem that western medicine is difficult to exert an ideal effect. And traditional Chinese medicine decoctions have a great impact on clinical efficacy, large dosage and inconvenient to carry

Method used

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  • Anti-influenza medicine and preparation method thereof
  • Anti-influenza medicine and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1, the anti-influenza medicine, the raw materials are 1 to 3 parts of Artemisia annua, 1 to 3 parts of Radix Isatidis, and 1 to 3 parts of Trollius in parts by weight.

Embodiment 2

[0024] Embodiment 2, the anti-influenza medicine, the raw materials are 1 or 3 parts of Artemisia argyi, 1 or 3 parts of Radix Radix, and 1 or 3 parts of Trollius in parts by weight.

Embodiment 3

[0025] Example 3, the anti-influenza medicine is obtained according to the following preparation method. In the first step, the required amount of Radix isatidis is crushed into coarse powder of Radix Radix, and water of 6 to 10 times the weight of coarse powder of Radix Radix is ​​added to the coarse powder of Radix Radix. Soak for 24h to 48h, reflux extraction for 2 to 4 times, the temperature of each reflux extraction is 80°C to 110°C, the time of each reflux extraction is 0.5h to 1.5h, and each reflux extraction is filtered to obtain the water extract and medicine dregs, and then add 6 to 10 times the weight of Radix Radix Radix to the filtered medicinal dregs for the next extraction, after reflux extraction for 2 to 4 times, combine the water extracts obtained each time to obtain water Extract the mixed solution, concentrate the water-extracted mixed solution under reduced pressure to obtain a clear paste with a density of 1.22 to 1.25 at a temperature of 60°C, and then ...

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Abstract

The invention relates to the technical field of cold medicine and its preparation method, and relates to an anti-influenza medicine and a preparation method thereof; the raw materials of the anti-influenza medicine include 1 to 3 parts of Artemisia annua and 1 to 3 parts of Radix Radix by weight. 3 parts, 1 to 3 parts of nasturtium. The average IC50 of the anti-influenza medicine of the present invention is 115.86 μ g / ml, 132.28 μ g / ml respectively to A and B influenza virus, and the average TI is 8.8, 7.7; The 0.2 g / kg dose group of the anti-influenza medicine of the present invention can Significantly prolong the survival days of influenza A virus-infected mice and reduce the mortality rate; the 0.1g / kg and 0.2g / kg dose groups can obviously inhibit the lung index value, and the average inhibition rate is 19.4% and 28.0% respectively; the anti-epidemic effect of the present invention Cold medicine has certain in vivo and in vitro anti-influenza virus effects, which provides a pharmacological basis for its use in the treatment of influenza.

Description

technical field [0001] The invention relates to the technical field of medicine for colds and a preparation method thereof, and relates to an anti-influenza medicine and a preparation method thereof. Background technique [0002] Influenza (flu for short) is an acute respiratory infectious disease caused by influenza virus (IFV), which can cause various complications such as myocarditis, pneumonia, and bronchitis. It usually manifests as general malaise, chills, and fever, accompanied by symptoms of upper respiratory tract infection such as headache, sore throat, and cough. It has the characteristics of high incidence, rapid onset, rapid spread, wide prevalence, large variability, strong infectivity and certain mortality. [0003] Influenza is an acute respiratory infectious disease caused by influenza virus that endangers human health, often causing seasonal global or local pandemics. The "Spanish flu" pandemic of 1918 killed more than 20 million people worldwide. Then t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P31/16
Inventor 邢建国何承辉古丽斯坦·阿吾提姜雯
Owner XINJIANG INST OF MATERIA MEDICA