Application of ginger powder in preparation of drugs for treating viral influenza
A technology for viral colds and ginger powder, applied in antiviral agents, drug combinations, powder delivery, etc., can solve the problems of high infectivity and high incidence of viral colds
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Embodiment 1
[0058] Example 1: H1N1 Infected Animals
[0059] For the detailed mouse breeding method and H1N1 infection method in this example, refer to the paper "Protective Effect of Xiaoer Ganmao Granules on Acute Lung Injury Induced by H1N1 Influenza Virus in Mice" by Zhu Haiyan, Cen Lifeng, Shi Xunlong, Duan Juanhui and Dai Zhi ("Chinese Proprietary Medicine "Volume 42, Issue 3, March 2020). This reference is incorporated by reference in its entirety into this application.
[0060] Virus strain Influenza virus type A1 (H1N1) mouse lung-adapted strain FM1 (batch number 20171002), provided by the Institute of Pharmaceutical Biotechnology, Chinese Academy of Medical Sciences, passed down and preserved by our laboratory (BSL-2 level), this laboratory has been filed and has operation Experimental qualification of influenza virus.
[0061] In this example, Babl / C mice were used, SPF level, male, initial body weight 17-18g, purchased from Sipro-Bikay Laboratory Animal Co., Ltd. (certific...
Embodiment 2
[0063] Embodiment 2: the change of animal body weight after ginger powder treats animal virus influenza
[0064] The mice were randomly divided into normal group, virus control group, positive drug control group (Rib group) and low, medium and high dose groups of ginger powder according to body weight. The ginger powder in the picture is also known as meal raw powder or SSF.
[0065] According to the dose, accurately weigh the drug, add 0.5% CMC, prepare the corresponding concentration, and dissolve / suspend by ultrasonication for 15 minutes. CMC is Carboxymethyl Cellulose (CMC), a water-soluble cellulose ether obtained by chemically modifying natural cellulose.
[0066] The mice in the normal group were given 0.5% CMC; the virus control group was given 0.5% CMC; the positive drug control group was given ribavirin 0.25g / kg; 300mg / kg, 600mg / kg.
[0067] The time for the first administration was 2 hours after the H1N1 FM1 virus nasal drop infection, and the interval between ...
Embodiment 3
[0075] Embodiment 3: the situation of animal death after ginger powder treats animal viral influenza
[0076] The situation of animal death after ginger powder treats animal virus influenza is as table 2 and Figure 2-4 shown.
[0077] Table 2: Death situation table of mice after infection (observation in 10 days)
[0078]
[0079] The results in Table 2 show that the survival rate of the middle-dose and low-dose mealy powder is 66.7% at 7 days (the last administration), which is 33.4% higher than that of the virus group. The 9-day (two days after drug withdrawal) survival rates were 16.6% and 33.3% for the medium dose and low dose of meal powder, which were significantly higher than those of the virus group (0.0%) and ribavirin group (0.0%).
[0080] figure 2 and image 3 It is a mouse weight-time scatter diagram, through which the body weight of mice at different times and different intervention methods can be clearly observed. figure 2 The results showed that th...
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