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Method for extracting tenuifolia volatile oil and for treating cold and preparation method of preparation

An extraction method and a technology of volatile oil, which are applied in the field of preparation of anti-cold medicine, can solve the problems of slow effect, large side effects, and large side effects, and achieve the effects of small dose, good anti-inflammatory, and improved stability

Inactive Publication Date: 2005-08-24
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although through many years of research, some medicines have been developed in the world to prevent and treat influenza. The current clinical medicines for treating colds are mainly divided into two types: western medicine and traditional Chinese medicine, western medicine such as amantadine (amantadine), rimantadine ( rimantadine), ribavirin (ribavirin), etc., although they have the advantages of rapid effect, they have relatively large side effects. For example, many western medicine anti-cold medicines are banned because of containing PPA with great side effects; in comparison, traditional Chinese medicine And its active ingredients have fewer side effects, but the anti-cold traditional Chinese medicines currently on the market have good curative effects, but their effects are slow and cannot meet the needs of people's modern and fast-paced life.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The extraction method of embodiment 1, Schizonepeta volatile oil, its extraction step is:

[0040] (1) Take 3.31 kg of nepeta panicles, add 10 times the amount of water, and steam distill for 6 hours;

[0041] (2) Separation with an oil-water separator to obtain 33.0 g of water-containing Nepeta volatile oil;

[0042] (3) Freeze at -12°C for 24 hours, remove the ice and water, and obtain 31.5 g of nepeta volatile oil.

Embodiment 2

[0043] Embodiment 2, the preparation method of hard capsule Jing-Jingan capsule of the present invention, its preparation steps are:

[0044] (1) Take 31.5g of Nepeta volatile oil, add 8 times the amount of β-cyclodextrin (252g) and 20 times the amount of β-cyclodextrin in distilled water (5.04L), and disperse at a high speed for 30 minutes with a disperser at 30°C ;

[0045] (2) The encapsulation liquid is spray-dried, the air inlet temperature is set to 160°C, and the air outlet temperature is 70°C to obtain the inclusion material and spray dry powder;

[0046] (3) Add 10ml of 95% ethanol to every 250g of spray-dried powder, dry granulate, and fill 1000 capsules, each containing 0.25g, to get final product.

Embodiment 3

[0047] Embodiment 3, the preparation method of soft capsule of the present invention-Qingfei soft capsule, its preparation step is:

[0048] (1) Take 2g of Nepeta volatile oil, add 31.35g of polyethylene glycol-400 and 1.65g of glycerin, and stir for 2 hours at 30°C to disperse the medicinal solution;

[0049] (2) making soft capsules from the dispersed medicine;

[0050] (3) Wash the compressed soft capsules with 75% ethanol, and dry them at 25°C for 72 hours to obtain the final product.

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PUM

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Abstract

The invention discloses a Herba schizouepetae naphtha, preparing method and pharmic effect of its preparation. It uses Herba schizouepetae spike as raw material, adds in water, distills to separate to obtain aqueous jingjie naphtha, freezes, and then eliminates ice and water to obtain jingjie naphtha, then uses the jingjie naphtha as active substance to add in assistant materials with different drug forms, so as to make various drug forms: capsule (hard capsule and soft capsule) and spray. The jingjie naphtha and its preparations-jingan capsule and qingfei soft capsule, have better effects of resisting inflammation, cleaning heat, sweating and anti-bacterium, and antivirus, and have advantage of little dosage.

Description

1. Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a preparation method of a medicinal active ingredient extracted from a traditional Chinese medicinal material and a preparation thereof and an application in preparation of an anti-cold medicine. 2. Background technology [0002] A common cold is a common frequently-occurring disease caused by a cold virus. It is mainly divided into two types: the common cold and influenza. Symptoms include fever, headache, muscle pain, runny nose, and sore throat. A cold looks like a "minor illness", but if it is not treated in time, it will easily lead to a variety of serious complications, such as viral myocarditis, etc., which may be life-threatening in severe cases, especially influenza, which is caused by influenza virus It is an acute respiratory infectious disease with high morbidity, widespread prevalence and rapid spread. In 1918, 1957 and 1968, three major in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K9/48A61P31/00
Inventor 丁安伟张丽丁婕
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE