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A kind of preparation method and application of Twelve Wenjing Pills

A technology of Twelve Wenjing Pills and wine making, which is applied in the field of preparation of Twelve Wenjing Pills, which can solve the problems of large dosage for patients, influence on application, and rough process, and achieve the effect of reducing dosage and increasing compliance

Inactive Publication Date: 2016-03-23
李梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Twelve Wenjing Pills, but the method of powdering is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the This product is used clinically

Method used

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  • A kind of preparation method and application of Twelve Wenjing Pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 90g of Evodia rutaecarpa, 60g of angelica, 60g of wine-made Chuanxiong, 60g of white peony root, 60g of donkey-hide gelatin, 60g of cinnamon, 60g of Moutan bark, 15g of ginger, 60g of Codonopsis pilosula, 90g of Pinellia (made), 120g of Radix Ophiopogon, 60g of honey-roasted licorice, and add In the CO2 supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug·min, and the extraction time is 150min to obtain supercritical The extract is crushed into fine powder, sieved, mixed evenly, 50g of refined honey and appropriate amount of water are added to every 100g of powder, pan-pilled, and dried at low temperature to obtain 600g of water-panned pills, each weighing 0.3g.

Embodiment 2

[0018] Take 90g of Evodia rutaecarpa, 60g of angelica, 60g of wine-made Chuanxiong, 60g of white peony root, 60g of donkey-hide gelatin, 60g of cinnamon, 60g of Moutan bark, 15g of ginger, 60g of Codonopsis pilosula, 90g of Pinellia (made), 120g of Radix Ophiopogon, 60g of honey-roasted licorice, and add to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, mixed evenly, and 50g of refined honey and an appropriate amount of water are added to each 100g of powder, pan-pilled, and dried at low temperature to obtain 600g Shuipan pills, each weighing 0.3g.

Embodiment 3

[0020] Take 90g of Evodia rutaecarpa, 60g of angelica, 60g of wine-made Chuanxiong, 60g of white peony root, 60g of donkey-hide gelatin, 60g of cinnamon, 60g of Moutan bark, 15g of ginger, 60g of Codonopsis pilosula, 90g of Pinellia (made), 120g of Radix Ophiopogon, 60g of honey-roasted licorice, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, mixed evenly, and 50g of refined honey and appropriate amount of water are added to each 100g of powder, pan-pilled, and dried at low temperature to obtain 600g Shuipan pills, each weighing 0.3g.

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Abstract

The invention provides a preparation method of a twelve body channel warming pellet. The pellet is prepared from 90 g of fructus evodiae, 60 g of angelica sinensis, 60g of wine-treated ligusticum wallichii, 60 g of radix paeoniae alba, 60 g of donkey-hide gelatin, 60 g of cinnamon, 60 g of moutan bark, 15 g of ginger, 60 g of codonopsis pilosula, 90 g of pinellia ternate (prepared), 120 g of radix ophiopogonis and 60 g of honey-fried licorice root through supercritical fluid extraction. The content of effective components is increased and the dosage is reduced. The invention further provides an application of the twelve body channel warming pellet in preparing a medication for inhibiting cell proliferation of a melanoma cell M14.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Twelve Wenjing Pills. Background technique [0002] Twelve Wenjing pills are recorded in the standard WS3-B-0005-89 of the Ministry of Health, and the prescription is 90g of Evodia rutaecarpa, 60g of angelica, 60g of Chuanxiong (wine), 60g of white peony, 60g of donkey-hide gelatin beads, 60g of cinnamon, 60g of Moutan bark, and 15g of ginger , Codonopsis 60g, Pinellia (made) 90g, Ophiopogon japonicus 120g, licorice (honey roasted) 60g, the above twelve flavors, crushed into fine powder, sieved, and mixed. Add 50g of refined honey and appropriate amount of water to every 100g of powder, make pills, and dry at low temperature to get it. It can warm the meridians and dispel cold, nourish blood and remove blood stasis. It is used for Chong Ren Deficiency and Cold, stagnation of blood stasis, irregular menstru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K9/20A61P35/00
Inventor 李梅
Owner 李梅