Unlock instant, AI-driven research and patent intelligence for your innovation.

Neutral calcium phosphate bone cement and preparation method thereof

A technology of bone cement and calcium phosphate, applied in medical science, prosthesis, etc., to achieve the effect of simple preparation method, high mechanical strength and good effect

Inactive Publication Date: 2015-04-22
SHANGHAI NAT ENG RES CENT FORNANOTECH
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the above backgrounds and deficiencies, the present invention provides a novel bone cement and its preparation method. By adjusting the preparation process and components of the bone cement, the mechanical strength of the bone cement can be improved, and the strong acidity caused by the traditional method can be effectively avoided. question

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Neutral calcium phosphate bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 86 g of calcium hydrogen phosphate dihydrate and 25 g of calcium carbonate, add them to 165 mL of water, ball mill and mix well. Then the water was distilled under reduced pressure, and dried in a vacuum drying oven at 80° C. to obtain a mixed powder. The powder was fired in the middle of a furnace at 900°C for 15 hours, and then the bone cement dispersion was obtained by wet ball milling. The dispersion liquid is centrifuged and dried to obtain the main component of the bone cement powder, and the powder size is 300-800 nm.

Embodiment 2

[0028] 96 g of the main component of bone cement powder and 4 g of hydroxyapatite were ground uniformly with a mortar to obtain bone cement powder. The solidification solution composed of 20% citric acid-1% hydroxypropyl methylcellulose was mixed with bone cement powder at a liquid-solid ratio of 0.5 mL / g, and the initial setting time was determined to be 11 min according to the standard ASTM C191. The apparent density of the bone cement after curing is 1.45 g / cm 3 , The collapse coefficient is 1.5%. When it is added to water, the solution is neutral. After standing for a week, the pH of the test solution remains unchanged, such as figure 1 As shown, the pH of the aqueous solution remains neutral over a long time scale.

Embodiment 3

[0030] 91 g of the main component of bone cement powder, 4 g of hydroxyapatite and 5 g of sodium silicate were ground uniformly in a mortar to obtain bone cement powder. The solidification solution composed of 20% citric acid-1% hydroxypropyl methylcellulose was mixed with the bone cement powder at a liquid-solid ratio of 0.5 mL / g, and the initial setting time was determined to be 9 min according to the standard ASTM C191. The apparent density of the bone cement after curing is 1.48 g / cm 3 , Collapse coefficient 2.2%. When it is added to water, the solution is neutral. After standing for a week, the pH of the solution was basically unchanged, and the result was the same as figure 1 Similar to shown.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
sizeaaaaaaaaaa
densityaaaaaaaaaa
densityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a method belonging to the technical field of biomedical materials, and concretely relates to a neutral calcium phosphate bone cement and a preparation method thereof. The preparation method is characterized in that the preparation method comprises the following steps: preparing a bone cement powder main component by appropriately controlling reaction conditions; adding a certain amount of hydroxyapatite and silicate to the above powder, and fully and uniformly mixing to prepare bone cement powder; and blending the bone cement powder with a citric acid-containing solidification liquid according to a certain liquid / solid ratio to obtain neutral bone cement, and putting solidified bone cement in water to obtain a neutral solution. The preparation method of the neutral bone cement enriches the range of the bone cement powder, allows acidic solidification liquids to be widely applied in injectable bone cements, and has the advantages of simplicity, feasibility, good effect, suitableness for the popularization in different acidic solidification liquids, and large scale application.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a neutral calcium phosphate bone cement and a preparation method thereof. Background technique [0002] In some calcium phosphate bone cement systems, in order to better promote the solidification of bone cement powder and maintain high compressive strength, it is generally necessary to add a large amount of citric acid to the bone cement solidification solution [M. Anirban Jyoti, Applied Surface Science, 2010]. The fly in the ointment is that while citric acid effectively promotes the curing of bone cement and maintains a high compressive strength, it also often causes the bone cement to become strongly acidic. The presence of a large number of protons generally leads to cell death, severely limiting their in vivo applications. [0003] Aiming at the above backgrounds and deficiencies, the present invention provides a novel bone cement and its preparat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/12
Inventor 刘涛杨迪诚何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH