Detection method of inflammation-diminishing compound pierasma quassioides benn capsule

A technology of anti-inflammatory capsules and detection methods, which are applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve the problems of difficult determination and large quality differences, and achieve the effects of high precision and good repeatability.

Inactive Publication Date: 2014-03-26
江西南昌制药有限公司
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Problems solved by technology

[0003] In order to overcome the above-mentioned defects, the purpose of the present invention is to solve the problem that there are many impurity peaks in the detection spectrum of andrographolide content in the original standard, which is difficult to judge and has a large quality difference. However, a detection method for compound Kumu Xiaoyan capsule is proposed

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Embodiment Construction

[0022] Below in conjunction with specific embodiment and control test result the present invention is described in detail:

[0023] A detection method for compound Kumu Xiaoyan capsules, which comprises two detection steps of TLC identification and content determination,

[0024] In the TLC identification step:

[0025] (1) Take 2g of the content of Compound Kumu Xiaoyan Capsules, grind it finely, add 30ml of ethanol, ultrasonicate for 20 minutes, filter, evaporate the filtrate to dryness, add 5ml of absolute ethanol to dissolve the residue, filter, and take the subsequent filtrate as the test sample solution;

[0026] Take another 0.5 g of Andrographis paniculata reference medicinal material, and prepare the reference medicinal material solution in the same way;

[0027] According to the thin-layer chromatography test, draw each 5ul of the above-mentioned need testing solution and the reference medicinal material solution, and respectively spot on the same silica gel GF...

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Abstract

The invention relates to a detection method of an inflammation-diminishing compound pierasma quassioides benn capsule, and belongs to detection methods of drugs. The detection method comprises two detection steps of TLC (thin-layer chromatography) identification and content measurement. The capsule comprises common andrographis and pierasma quassioides benn; when the common andrographis is decocted with water for 2 times, a large amount of impurities can be easily extracted; when the pierasma quassioides benn is percolated by 80% hexanol, impurities cannot be easily extracted; a process of performing reflux extraction on a test product, filtering through neutral alumina (100-200-mesh), eluting by hexanol and performing sample introduction detection is added in the common andrographis content detection process, so that a result shows that an HPLC (high performance liquid chromatography) content measurement method is higher in precision, good in repeatability, simple, convenient and quick, and can be used for controlling the content measurement of the capsule and enabling the quality standard of the capsule to be more scientific.

Description

technical field [0001] The invention relates to a detection method of compound Kumu Xiaoyan capsule, which belongs to the detection method of medicines. Background technique [0002] At present, the original standard requires control of Andrographis paniculata, TLC identification and Andrographis paniculata content detection. However, in the production process, we often find that there are many impurity peaks on the content spectrum of Andrographis paniculata paniculata, which will seriously dry up the spectrum of andrographolide and affect the judgment. Contents of the invention [0003] In order to overcome the above-mentioned defects, the object of the present invention is to solve the problems that there are many impurity peaks in the andrographolide content detection spectrum in the original standard, which are difficult to judge and have large quality differences. However, a detection method for compound Kumu Xiaoyan capsules is proposed. [0004] In order to achiev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
Inventor 黄凤林熊建英邵青文陈颖
Owner 江西南昌制药有限公司
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