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82results about How to "Difficult to extract" patented technology

Misuse preventative, controlled release formulation

Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed therein. The second layer, which can be adjacent the first layer comprises a pharmaceutically active agent that can be the same or different from the pharmaceutically active agent in the microparticles in the first layer. The composition further comprises a superabsorbent material (for example, polycarbophil) disposed within the first layer, the second layer, or both the first layer and the second layer. When intact, the pharmaceutically active agent is released from the second layer faster than the pharmaceutically active agent in the first layer. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the composition. Also disclosed is a method of using the misuse preventative, controlled release composition to deliver at least one pharmaceutically active agent to a mammal, for example, a human, in need thereof.
Owner:PALADIN LABS (BARBADOS) INC

Multi-sensor merging based super-close distance autonomous navigation apparatus and method

The present invention discloses a multi-sensor merging based super-close distance autonomous navigation apparatus and method. The apparatus includes a sensor subsystem, an information merging subsystem, a sensor scanning structure, and an orientation guiding structure, wherein a visible light imaging sensor and an infrared imaging sensor are combined together, and data are acquired by combining a passive measurement mode composed of an optical imaging sensor and an active measurement mode composed of a laser distance measuring sensor. Autonomous navigation is divided into three stages, that is, a remote distance stage, implemented by adopting a navigation mode where a binocular visible light imaging sensor and a binocular infrared imaging sensor are combined, a close distance stage, implemented by adopting a navigation mode where a binocular visible light imaging sensor, a binocular infrared imaging sensor and a laser distance measuring sensor array are combined, and an ultra-close distance stage, implemented by adopting a navigation mode of a laser distance measuring sensor array. Through the present invention, the field of view and the exploration range are widened, the problem of shielding existing in passive measurement is effectively solved, the precision of data measurement is ensured, and the navigation efficiency and the safety and reliability of navigation are improved.
Owner:HUAZHONG UNIV OF SCI & TECH

Method for identifying microcrack direction in plate based on nonlinear frequency mixing technology of Lamb waves

The invention discloses a method for identifying a microcrack direction in a plate based on a nonlinear frequency mixing technology of Lamb waves. The method includes, firstly, extracting a sum frequency signal and a difference frequency signal in a damage response signal by adopting a pulse inversion method; obtaining a directional mode pattern of a nonlinear scattering coefficient beta through the extracted sum frequency signal and difference frequency signal; and determining the maximum forward scattering point and the minimum backward scattering point of the Lamb wave, and taking the direction vertical to the connecting line of the maximum forward scattering point and the minimum backward scattering point of the Lamb wave as the direction of the micro-crack, thereby realizing the identification of the direction of the micro-crack. According to the invention, the Lamb wave excited by frequency mixing interacts with the nonlinear medium to generate a new frequency component; the sumfrequency and difference frequency effective frequency components in the damage response signal are effectively extracted through a pulse inversion method, the microcrack direction is recognized by researching the nonlinear scattering degree of Lamb waves in different directions of the microcrack, and the technical problems that the amplitude is too small, and the sum frequency and difference frequency signals with weak signals are not easy to extract and recognize are effectively solved.
Owner:NANJING UNIV OF TECH
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