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Preparation method and medical application of antipyretic-analgesic and anti-inflammatory part in Polybia spp. insects

A technology of wasp and purpose, applied in the field of medicine, can solve problems such as failure to form large-scale production capacity and low level of industrial production support, and achieve the effects of inhibiting pain, reducing inflammation and immune inflammatory response

Inactive Publication Date: 2014-04-02
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with developed countries, there is still a relatively obvious gap in the research and development of my country's TTS system, especially the low level of supporting industrial production, which has not yet formed a large-scale production capacity

Method used

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  • Preparation method and medical application of antipyretic-analgesic and anti-inflammatory part in Polybia spp. insects
  • Preparation method and medical application of antipyretic-analgesic and anti-inflammatory part in Polybia spp. insects
  • Preparation method and medical application of antipyretic-analgesic and anti-inflammatory part in Polybia spp. insects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 : Preparation of effective parts of Vespa orientalis venom polypeptide and coating agent

[0045] 1.1 Collection of crude venom from Vespa orientalis:

[0046] Vespa orientalis was collected from Pu'er City, Yunnan Province. The bee body specimen was identified as Polybia orientalis Saussure (Polybia orientalis Saussure) by Professor Mao Benyong of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali College, Yunnan Province. Wasp venom collection device: use the auxiliary cover type bee venom collector modified by the engineering research center, wooden frame, 80 cm long, 50 cm wide; embedded with 4 pieces of 20 cm long / 33 cm wide poisonous glass; input voltage 9V , output automatic intermittent pulsating voltage; method of collecting wasp venom: place the poison collecting device in front of the hive, collect poison for the worker bees of the Vespa orientalis colony according to the routine poison c...

Embodiment 2

[0051] Example 2 : The active part of the vespa vespa venom polypeptide and the preparation of its hydrogel and cataplasm

[0052] 2.1 Collection of the crude venom of Vespa variegata:

[0053] Vespa stigma was collected from Ruili City, Yunnan Province. The bee body specimen was identified as Polybia stigma Smith (Vaspa stigma) by Professor Guo Yunjiao of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province. Wasp venom collection device: use the auxiliary cover type bee venom collector modified by the engineering research center, wooden frame, 80 cm long, 50 cm wide; embedded with 4 pieces of 20 cm long / 33 cm wide poisonous glass; input voltage 9V , output automatic intermittent pulsating voltage; collection method of wasp venom: put the unpainted poison collection device in front of the hive, collect venom from the worker bees of the vespa colony according to the routine poison collectio...

Embodiment 3

[0060] Example 3 : Preparation of poultice from the active part of Vespa vesperus Sumatra venom polypeptide

[0061] 3.1 Collection of the crude venom of Vespa spp.:

[0062] Vespa Sumatranis was collected from Menghai, Yunnan Province. The bee body specimen was identified as Polybia sumatrensis Saussure by Professor Yang Zizhong of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province. The basic device for poison collection uses a sub-cap type bee venom collector modified by the engineering research center, with a wooden frame, 80 cm long and 50 cm wide; 4 pieces of poisonous glass with a length of 20 cm / width of 33 cm are embedded; the input voltage is 9V, Output automatic intermittent pulsating voltage; The wooden frame is painted red with red paint in advance; The wooden frame is pre-smeared 20 milliliters concentration is the honeycomb and honeycomb body extract volatile solution (prep...

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Abstract

The invention relates to a preparation method and medical application of an antipyretic-analgesic and anti-inflammatory part in Polybia spp. insects. The effective part is prepared from Polybia spp. rough melittin by using a dialysis membrane with MWCO (Molecular Weight Cut Off) of 15KDa to dialyze and carrying out freeze-drying or decompressing concentration drying on eluate. Various transdermal absorbing drugs of the effective part can effectively prolong a hot plate stimulation pain threshold value of a mouse, can obviously inhibit ear swelling of the mouse, which is caused by xylene, and inhibit capillary permeability of the mouse from being increased due to acetic acid, and can obviously reduce adjuvant arthritis joint swelling of the mouse and reduce the joint circumference. Predictably, the insect polypeptide antipyretic-analgesic and anti-inflammatory part and the transdermal absorbing drugs thereof are used for preparing antipyretic-analgesic and anti-inflammatory biochemical drugs for treating acute and chronic inflammation, relieving pain before and after various operations and carrying out analgesic treatment on acute and chronic pain such as pain generated in beautifying, microscopic examination, burn and scald process, neuropathic pain, cancer pain and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, the invention relates to a preparation method and a medical application of an analgesic and anti-inflammatory effective fraction from Polybia spp. insects. The effective part is prepared from the crude venom of the genus Heterogastricus through a modern extraction process. Various transdermal absorption preparations of the effective part have significant effects on analgesia, anti-acute and chronic inflammation and autoimmune inflammation. It can be expected that the The effective part and its transdermal absorption preparation are used for the preparation of anti-inflammatory and analgesic biochemical drugs for acute and chronic inflammation, as well as for various types of surgical pain relief, relief or termination of cosmetology, microscopic examination, pain associated with burns, neuropathic pain and acute and chronic pain such as cancer pain. The anti-inflammatory and analge...

Claims

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Application Information

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IPC IPC(8): A61K38/17C07K14/435C07K1/34A61P29/00A61P25/04
Inventor 赵昱陈艳兰罗廷顺张荣平郑园园巫秀美
Owner DALI UNIV
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