Silk fibroin/alginate hydrogel material and preparation method thereof

Abstract

The invention discloses a silk fibroin/alginate hydrogel material and a preparation method thereof. The preparation method comprise the following steps: (a) preparing a silk fibroin solution; (b) preparing an alginate solution; (c) mixing the silk fibroin solution and the alginate solution according to a certain ratio, evenly stirring, adjusting the pH value of the mixed solution, allowing the mixed solution to stand still to carry reactions at a certain temperature so as to a generate jelly-like substance; wherein the mass ratio of the silk fibroin to the alginate is 99:1-1:99. The prepared silk fibroin/alginate hydrogel material overcomes the shortage of bad mechanical property of silk fibroin hydrogel materials; furthermore, the silk fibroin/alginate hydrogel material has a similar structure, composition and functions as those of the cell epimatrix, and is an ideal tissue engineering material.

Description

technical field

[0001] The invention relates to a hydrogel material and a preparation method thereof, in particular to a silk fibroin / alginate hydrogel material and a preparation method thereof. Background technique

[0002] Hydrogel is a kind of polymer functional material that integrates water absorption, water retention and controlled release. Its properties are similar to those of the extracellular matrix. After absorbing water, it can reduce friction and mechanical effects on surrounding tissues and improve the biological properties of the material. . Due to its unique water absorption, water retention and biomimetic properties, hydrogel materials can be used as drug sustained release agents, tissue engineering scaffold materials, etc. in the field of biomedicine.

[0003] Hydrogels include natural hydrogels and synthetic hydrogels. Natural hydrogel materials are mainly collagen (fibrin, glycoprotein, etc.), hyaluronic acid, alginic acid, chitosan, etc.; synthetic hydr...

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