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Application of molecular marker in diagnosing of parathyroid tumor

A technology of molecular markers and parathyroid glands, which is applied in the direction of analysis materials, measuring devices, instruments, etc., can solve the problem of less parathyroid gland tumors

Active Publication Date: 2014-04-09
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] At present, there are few research reports on the mechanism of occurrence and development of parathyroid tumors

Method used

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  • Application of molecular marker in diagnosing of parathyroid tumor
  • Application of molecular marker in diagnosing of parathyroid tumor
  • Application of molecular marker in diagnosing of parathyroid tumor

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Embodiment Construction

[0048] In the early stage, the present inventor conducted a gene expression profile study on the parathyroid gland through the operation method of the whole genome chip experiment, and identified some related differential genes, including CD24 and other genes. Further, this study used immunohistochemistry and real-time PCR to detect the protein levels of molecular markers CD24, HMOX1, VCAM1 or KCNA3 in parathyroid adenocarcinoma, parathyroid adenoma tissue, and normal parathyroid tissue and mRNA level expression, and its clinical significance and the relationship between them were preliminarily discussed.

[0049] 1. Whole transcriptome microarray experiment operation method

[0050] 1. Research object

[0051] A total of 23 parathyroid tissue samples and normal parathyroid tissue samples from patients with primary hyperparathyroidism in Peking Union Medical College Hospital were selected, including 5 cases of normal parathyroid tissue and 18 cases of primary hyperparathyroid...

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Abstract

The invention relates to application of a molecular marker in diagnosing of parathyroid tumor, in particular to application of one or more combination parts which are selectively combined to the molecular marker in preparation of a reagent for authenticating the parathyroid tumor. The molecular marker is selected from CD24, HMOX1, VCAM1 or KCNA3.

Description

technical field [0001] The present invention relates to the field of parathyroid tumor markers. In particular, the present invention relates to the use of molecular markers selected from CD24, HMOX1, VCAM1 or KCNA3 in the diagnosis of parathyroid tumors. Background technique [0002] CD24 is a glycosylated protein expressed on the surface of most B lymphocytes and neurofibroblasts. CD24 can promote the proliferation ability of tumor cells and increase the stretching motion of tumor cells. CD24 is one of the P-selectin ligands. CD24 was found to be highly expressed in non-melanomas. The sensitivities in basal cell carcinoma and squamous cell carcinoma were 81% and 100%, and the specificities were 67% and 71%, respectively. See ,Miller E, Shapira S, Gur E, Naumov I, Kazanov D, Leshem D, Barnea Y, Meshiach Y, Gat A, Sion D et al:Increased expression of CD24in nonmelanoma skin cancer.The International journal of biological markers2012,27( 4): e331-336.. It has also been repor...

Claims

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 赵玉沛赵建国廖泉胡亚牛哲禹邢小平夏维波
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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