8 results about "Parathyroid Tetany" patented technology

This invention discloses a parathyroid tissue transplantation device, belonging to the field of transplantation device technology, including a syringe, a cutting device, and a pusher. The cutting device has the same size as the inner wall of the syringe, and a through groove runs through the top surface of the cutting device. A material hopper is installed in the through groove, and the bottom surface of the material hopper is equipped with dense blades. A squeezing rod is placed in the material hopper, and a pusher plate is fixed at one end of the squeezing rod. The pusher plate has the same size as the inner wall of the material hopper. A drive component is installed inside the cutting device, which controls the rotation of the cutting blades. By setting up the syringe, cutting device, and pusher, the parathyroid tissue can be efficiently processed into a homogenate, realizing seamless linkage of tissue loading, cutting, and pushing. The entire process is completed in a closed structure, reducing tissue exposure, contamination, and residual loss. It realizes an integrated operation of immediate harvesting, processing, and transplantation during surgery, greatly improving the operation efficiency, standardization, and tissue survival rate of parathyroid tissue transplantation, and reducing the risk of postoperative hypoparathyroidism.

The invention provides a PTH1R agonist compound, a pharmaceutical composition and application of the PTH1R agonist compound. The compound has good PTH1R agonist activity and is used for treating diseases and / or diseases related to parathyroid hypofunction and / or osteoporosis and preparing drugs for the diseases and / or diseases.

The invention discloses a cinacalcet-containing transdermal patch as well as a preparation method and application thereof. The transdermal patch comprises a high-molecular matrix layer, wherein the high-molecular matrix layer comprises cinacalcet, a silicone pressure-sensitive adhesive and one or more high-molecular polymers selected from a water-insoluble cellulose derivative, polyvinylpyrrolidone and a polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The transdermal patch disclosed by the invention is good in drug permeability and colloid application performance, high in safety, free of skin irritation, high in stability and good in uniformity, and can meet the requirements of clinically treating hyperparathyroidism or hypercalcemia.

The invention belongs to the technical field of chemical raw material medicines, and particularly relates to an aryl alkyl amine compound as well as a preparation method and application thereof. The structure of the aryl alkyl amine compound is shown as a formula I. Experiments prove that the allosteric agonist effect of the compound provided by the invention on a calcium-sensitive receptor is superior to or equivalent to that of Evocalpet, and the aryl alkyl amine compound has potential in preparation of drugs for treating secondary hyperparathyroidism. Formula I

The application provides a camera equipment for an electric knife, and belongs to the technical field of auxiliary camera equipment for electric knives, and comprises an electric knife provided with a binocular depth camera and a processor. The processor acquires a synchronous video stream through the binocular depth camera, and recognizes a recurrent laryngeal nerve and parathyroid region and boundary points thereof by using a pre-trained neural network, and then constructs three-dimensional coordinates of the boundary points with the end of the electric knife as the origin. The system continuously tracks the movement of the boundary points, and predicts the future positions by analyzing the historical trajectories. If the boundary point closest to the electric knife in the predicted points exceeds a safety threshold, the system will issue a real-time warning. The equipment can dynamically identify and predict the movement of key tissues, and assist the doctor to actively avoid intraoperative risks.

The application relates to a parathyroid real-time detection method based on Anchor-Free and space-time consistency. An Anchor-Free base convolutional neural network and a feature pyramid model are used to perform feature extraction on a detection image to generate a pyramid multi-scale feature map group, then a shared detection head is used to obtain a plurality of scale corresponding classification confidence maps, a center confidence map and a target frame regression map, and then the classification confidence map and the center confidence map are multiplied to obtain a center classification confidence map. A space-time classification memory map is constructed, information is extracted by using the center confidence map, a time sequence classification result map is generated, and the time sequence classification result map and the center confidence map are fused to generate a final classification confidence map. The application enhances the detection effect and the adaptability of the detection network, and alleviates the target drift problem of the detector under complex conditions such as shielding, fog and illumination when the parathyroid is encountered.

One embodiment provides a tightly targeted minimally invasive therapy (TTMIT) parathyroid tissue ablating instrument. A substance that cytotoxically ablates parathyroidal tissue during application in the parathyroidal tissue of therapeutically sufficient units of an electromagnetic energy having a frequency only ranging from ultraviolet to visible to near infrared. A substance delivery device is configured to introduce the substance into the parathyroidal tissue. An electromagnetic energy treatment device is configured to apply the therapeutically sufficient units of the electromagnetic energy within a thermal range that is non-cytotoxic to the parathyroidal tissue to the substance after the substance has been introduced by the substance delivery device. A sensor is configured to monitor activation of the substance as the therapeutically sufficient units of the electromagnetic energy are applied. The electromagnetic energy treatment device is further configured to modulate applying the therapeutically sufficient units of the electromagnetic energy once the substance has been activated.