40 results about "Parathyroid Tetany" patented technology

The invention discloses an RGD-click chemical crosslinking siRNA nano-carrier, a preparation method thereof and application of the nano-carrier in preparation of a medicine for treating secondary thyroidism, and belongs to the technical field of medicines.The nano-carrier is RGD-PEG-PLys (N), and the preparation method of the nano-carrier comprises the steps of synthesis of PLys (ss-DBCO), synthesis of RGD-PEG-PLys (N) and the like. According to the application, the nano-carrier is used for preparing siRNA composite nanoparticles; vascular endothelial targeting (RGD), dynamic stability (click crosslinking) and microenvironment responsiveness (disulfide bond) are organically combined for the first time to achieve mutual synergistic interaction, and the effect ceiling of an existing material is broken through; according to the siRNA composite nanoparticle, the silence effect of the PTH gene as long as 70 days can be achieved through single intravenous injection, the PTH inhibition rate is larger than 85%, the siRNA accumulation amount in parathyroid gland tissue is remarkably increased through RGD targeting (8.6 times that of a non-targeting group), the liver and kidney distribution amount is reduced by 60%, and the system toxicity is controllable.

A local positioning system (LPS) is provided. The LPS includes at least three local position tracking devices, each further including one or more of: a clock synchronized to the clock in each of the other devices; a transmitter transmitting signals over time synchronized to the clock; and a receiver receiving the signals over time from the other devices. The LPS further includes a processor operatively coupled to at least one of the devices and that is configured to: obtain for each of the signals a location of the device that transmitted that signal; produce one or more representations of at least a part of a living body based on at least one of one or more of the locations and one or more further representations of the at least the part of the living body, each of the representations including one or more temporal frames; and to provide output.

This invention discloses a parathyroid tissue transplantation device, belonging to the field of transplantation device technology, including a syringe, a cutting device, and a pusher. The cutting device has the same size as the inner wall of the syringe, and a through groove runs through the top surface of the cutting device. A material hopper is installed in the through groove, and the bottom surface of the material hopper is equipped with dense blades. A squeezing rod is placed in the material hopper, and a pusher plate is fixed at one end of the squeezing rod. The pusher plate has the same size as the inner wall of the material hopper. A drive component is installed inside the cutting device, which controls the rotation of the cutting blades. By setting up the syringe, cutting device, and pusher, the parathyroid tissue can be efficiently processed into a homogenate, realizing seamless linkage of tissue loading, cutting, and pushing. The entire process is completed in a closed structure, reducing tissue exposure, contamination, and residual loss. It realizes an integrated operation of immediate harvesting, processing, and transplantation during surgery, greatly improving the operation efficiency, standardization, and tissue survival rate of parathyroid tissue transplantation, and reducing the risk of postoperative hypoparathyroidism.

The invention provides a combined preparation of parathyroid hormone analogue drug loaded core-shell microspheres and a method for preparing the parathyroid hormone analogue drug loaded core-shell microspheres. The parathyroid hormone analogue drug-loaded core-shell microsphere combined preparation comprises a first core-shell microsphere, a second core-shell microsphere and a third core-shell microsphere. The ratio of the first core-shell type microsphere to the second core-shell type microsphere to the third core-shell type microsphere is 1: 1: 1, and the drug release time of the first core-shell type microsphere, the drug release time of the second core-shell type microsphere and the drug release time of the third core-shell type microsphere are different. The first core-shell type microsphere is prepared from the following components in percentage by weight: 4.76 to 16.67 percent of parathyroid hormone analogue medicine and 83.33 to 95.24 percent of high-molecular polymer material. And the second core-shell type microsphere comprises the following components in percentage by weight: 4.76%-16.67% of parathyroid hormone analogue medicine and 83.33%-95.24% of high-molecular polymer material, wherein the parathyroid hormone analogue medicine accounts for 4.76%-16.67%, and the high-molecular polymer material accounts for 83.33%-95.24%. And the third core-shell type microsphere comprises the following components in percentage by weight: 4.76%-16.67% of parathyroid hormone analogue medicine and 83.33%-95.24% of high-molecular polymer material, wherein the parathyroid hormone analogue medicine accounts for 4.76%-16.67%, and the high-molecular polymer material accounts for 83.33%-95.24%.

To provide methods and compositions for regulating hyperparathyroidism.SOLUTION: One aspect of the disclosure is a method for preventing, halting or reversing the SHPT progression in a subject, e.g., a human adult, defined as an increase in iPTH by >10% from the pretreatment baseline, the method comprising effective administration of 25-hydroxyvitamin D to increase and maintain serum total 25-hydroxyvitamin D in the patient to a concentration greater than 50 ng / mL, optionally at least 50.8 ng / mL, optionally at least 51 ng / mL or at least 60 ng / mL, and thereby preventing, halting, or reversing SHPT progression in the patient.SELECTED DRAWING: None

The utility model relates to the technical field of surgical equipment, and discloses a photoelectric integrated patient interface box and a surgical device. The patient interface box outputs exciting light with a specific wavelength, the exciting light is guided into a detected object through the probe, the detected object generates autofluorescence after being excited by the exciting light, the autofluorescence is guided into the patient interface box through the probe, and the patient interface box obtains a fluorescence value from the autofluorescence and transmits the fluorescence value to the host through the communication cable. Judging whether the detected object is parathyroid gland or not; the host sends out current which passes through the patient interface box and is connected with a tested object through a second wire, the probe contacts with the tested object, and the current is transmitted to the tested object to form a current loop. A detected object generates electromyographic signals after being electrically stimulated, the patient interface box collects the electromyographic signals through the first wire and transmits the electromyographic signals to the host along the cable, electromyographic waveforms are displayed on the host, and whether tissues are recurrent laryngeal nerves or not and whether the recurrent laryngeal nerves are damaged or not are judged through the electromyographic waveforms.

The present application provides a method and system for identifying parathyroid lesions in ultrasonic images, belonging to the technical field of image processing. Among them, a method for identifying parathyroid lesions in ultrasonic images includes obtaining the current ultrasonic image of a patient and the historical ultrasonic images in a database; determining the feature region in the current ultrasonic image according to the current ultrasonic image and the sample ultrasonic image; obtaining the size data, shape data, boundary clarity data, and echo characteristic quantity data of the feature region; calculating the basic attention degree data according to the region perimeter data, region area data, shape data, boundary clarity data, and echo characteristic quantity data; calculating the trend influence data according to the historical ultrasonic images and the growth distance data; analyzing the comprehensive attention degree data of the feature region according to the basic attention degree data and the trend influence data; adopting this solution can mark the feature region and help doctors observe the ultrasonic images of patients more intuitively.

The invention discloses a self-aligned cluster optical fiber probe for a parathyroid gland fluorescence detector. The self-aligned cluster optical fiber probe specifically comprises a cluster optical fiber probe, an excitation optical fiber, a collection optical fiber, a metal tube, an optical fiber plug group, a locking ring and a connector guide rail base, wherein the metal tube wraps the excitation optical fiber and the collection optical fibers, the collection optical fibers are uniformly arranged on the circumference of the excitation optical fiber and coaxially placed in the metal tube, and one end of the optical fiber is connected with the quick-release self-locking structure wrapping the light plug group. The rapid assembly and disassembly of the bundled optical fiber probe are realized through the rapid disassembly self-locking structure, and the fluorescence collection efficiency is improved by combining the bundled optical fiber.

The invention provides a PTH1R agonist compound, a pharmaceutical composition and application of the PTH1R agonist compound. The compound has good PTH1R agonist activity and is used for treating diseases and / or diseases related to parathyroid hypofunction and / or osteoporosis and preparing drugs for the diseases and / or diseases.

The invention discloses a cinacalcet-containing transdermal patch as well as a preparation method and application thereof. The transdermal patch comprises a high-molecular matrix layer, wherein the high-molecular matrix layer comprises cinacalcet, a silicone pressure-sensitive adhesive and one or more high-molecular polymers selected from a water-insoluble cellulose derivative, polyvinylpyrrolidone and a polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The transdermal patch disclosed by the invention is good in drug permeability and colloid application performance, high in safety, free of skin irritation, high in stability and good in uniformity, and can meet the requirements of clinically treating hyperparathyroidism or hypercalcemia.

The present invention relates to a process for the preparation of AMG416. A method for preparing AMG416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is an octa-amino acid selective peptide antagonist of the synthesized calcium-sensitive receptor. It has been developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease-mineral and bone disorders (CKD-MBD).

Pharmaceutical compositions of polymeric micelle cinacalcet suitable for intravenous or intraperitoneal administration, and methods of making and use thereof in the treatment of various diseases and disorders, such as hyperparathyroidism and hypercalcemia, are provided.

The present invention relates to a process for the preparation of AMG416. A method for preparing AMG416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is an octa-amino acid selective peptide antagonist of the synthesized calcium-sensitive receptor. It has been developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease-mineral and bone disorders (CKD-MBD).

This invention relates to the use of probiotic yeast cells that produce recombinant parathormone for therapeutic purposes, where probiotic cells that produce rhPTH developed for use in hypoparathyroidism treatment are first microencapsulated, placed into gelatin capsules and then orally administrated.

Methods for treating vitamin D insufficiency and secondary hyperparathyroidism in patients having CKD comprising administering repeat doses of 25-hydroxyvitamin D are disclosed. The methods comprise administering 25-hydroxyvitamin D in an amount effective to safely raise the patient's serum 25-hydroxyvitamin D level to greater than 90 ng / ml and / or to control the patient's serum ratio of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D to less than 20.

The invention discloses a parathyroid intraoperative identification device, comprising an excitation light unit, a calibration light unit, a signal acquisition unit and a data processing unit, wherein the excitation light emitted by the excitation light unit is transmitted to the tissue to be tested through a probe; the calibration light emitted by the calibration light unit is transmitted to the tissue to be tested through the probe; the signal acquisition unit collects a fluorescent signal I1 and a calibration light signal I2 emitted by the tissue to be tested; the data processing unit detects the intensity of the light source and determines whether the light source needs to be replaced, and at the same time, performs distance correction on the fluorescent signal I1 according to distance information, and determines whether the tissue to be tested is parathyroid tissue according to the corrected fluorescent signal; the invention has the advantages of performing distance correction on the fluorescent signal I1 to avoid detection errors caused by different distances between the probe and the tissue to be tested, detecting the intensity of the light source during the measurement process, avoiding the weakening of the fluorescent signal due to the decrease in the intensity of the excitation light source, thereby reducing the detection error.

1. The name of this design product: Medical laser fiber connector. 2. The purpose of this design product: used for the detection of open surgeries such as parathyroid surgery, and can perform spectral detection of wound tissue, etc. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention discloses a low-frequency modulation type intraoperative parathyroid gland tissue recognition method and system. The method comprises the steps that the regional position of suspected parathyroid gland tissue is determined; exciting light emitted by the laser control unit is modulated, and then a secondary throwing probe is used for conducting fluorescence excitation on the area position of the suspected parathyroid gland tissue; the secondary throwing probe is used for receiving a fluorescence signal generated by the regional position, and the fluorescence signal is amplified after being converted through a photomultiplier; and the amplified fluorescence signal is analyzed by using a demodulation module, so that the parathyroid gland tissue is identified. The interference of the background light is effectively removed in a double-demodulation mode of phase-locked demodulation and Fourier transform demodulation, the adaptability of the system to complex background interference is further improved, the real-time performance and the complexity processing capacity are considered at the same time, and the flexibility and sensitivity of the system are enhanced.

The invention belongs to the technical field of chemical raw material medicines, and particularly relates to an aryl alkyl amine compound as well as a preparation method and application thereof. The structure of the aryl alkyl amine compound is shown as a formula I. Experiments prove that the allosteric agonist effect of the compound provided by the invention on a calcium-sensitive receptor is superior to or equivalent to that of Evocalpet, and the aryl alkyl amine compound has potential in preparation of drugs for treating secondary hyperparathyroidism. Formula I

A method for intraoperatively determining a degree of parathyroid perfusion includes identifying parathyroid tissues of a living subject using autofluorescence detection with a fiber optic probe based fluorescence detection system; administering to the living subject a contrast agent with a dose; after a period of time of the administration, detecting fluorescence in an area of the parathyroid tissues with the fiber optic probe based fluorescence detection system, where the fluorescence is emitted from the contrast agent; and obtaining a detection level and / or a detection ratio for the parathyroid tissues from the detected fluorescence so as to determine a degree of parathyroid perfusion of each parathyroid. The method is not only unaffected by ambient light, but also has no need of images of the parathyroid tissues.

A tissue detection system includes a light source configured to illuminate tissue of interest. An imaging head including a detector is configured to acquire auto-fluorescence of the illuminated target tissue of interest responsive to the application of the light and generate one or more auto-fluorescence images of the target tissue of interest. A controller is configured to regulate operational control of the imaging head when acquiring, receiving, and processing images. If an intensity signal of the detected one or more auto-fluorescence images of the target tissue of interest leads to a determination of parathyroid tissue, the detector is configured to acquire laser speckle contrast images to determine the amount of perfusion of the target tissue of interest to distinguish well perfused parathyroid tissue having a low speckle contrast image from less perfused tissue having a high speckle contrast image. The less perfused tissue is identified a potential false positive.

The invention relates to the technical field of medical instruments, in particular to a grinding suction device for parathyroid gland autotransplantation, which comprises a needle tube and a needle head which are communicated with each other, and is characterized in that a piston assembly is arranged in the needle tube, a grinding assembly is arranged at the top of the needle tube, the outer side of the grinding assembly is symmetrically communicated with a conveying assembly, and one side of the grinding assembly is communicated with a suspension assembly; the grinding assembly comprises a sleeve and a grinding rod, a grinding head is fixedly connected to the bottom of the grinding rod, the bottom of the sleeve is fixedly connected with the top of the needle tube, a driving assembly is slidably connected into the sleeve and sleeves the grinding rod, the grinding head is located on the movement track of the driving assembly, and the bottom of the grinding head is fixedly connected with the piston assembly. The grinding assembly, the conveying assembly, the suspension assembly, the needle tube and the piston assembly are integrated, coherent operation from grinding to transplanting of parathyroid gland tissue is achieved, and the problems that in a traditional mode, tissue grinding is insufficient, a needle head is prone to being blocked, and operation is tedious are solved.

This application relates to the field of intelligent medicine, and particularly relates to a method, system and device for predicting EPH after parathyroidectomy based on images. It includes obtaining parathyroid images of a patient; extracting EPH highly correlated features based on the parathyroid images to predict EPH after surgery to obtain a prediction result; wherein, the construction process of the EPH highly correlated features is as follows: S1: obtaining a parathyroid image set, EPH grouping labels, and blood calcium concentration labels of the patient; S2: extracting primary features from the parathyroid image set based on the EPH grouping labels and blood calcium concentration labels; S3: performing feature screening on the primary features to obtain the EPH highly correlated features. This method predicts whether EPH occurs after parathyroidectomy for patients with secondary hyperparathyroidism through radiomics features, and has good clinical value.

The application provides a camera equipment for an electric knife, and belongs to the technical field of auxiliary camera equipment for electric knives, and comprises an electric knife provided with a binocular depth camera and a processor. The processor acquires a synchronous video stream through the binocular depth camera, and recognizes a recurrent laryngeal nerve and parathyroid region and boundary points thereof by using a pre-trained neural network, and then constructs three-dimensional coordinates of the boundary points with the end of the electric knife as the origin. The system continuously tracks the movement of the boundary points, and predicts the future positions by analyzing the historical trajectories. If the boundary point closest to the electric knife in the predicted points exceeds a safety threshold, the system will issue a real-time warning. The equipment can dynamically identify and predict the movement of key tissues, and assist the doctor to actively avoid intraoperative risks.

The invention discloses a parathyroid gland autologous implantation device, and relates to the technical field of parathyroid gland autologous implantation, and the parathyroid gland autologous implantation device comprises a double-cavity injector body; the combined module is arranged at the top end of the double-cavity injector body and comprises an air compression cavity and a rotary chopping cavity, an air pressure piston and a partitioning guide groove are movably connected into the air compression cavity, the air pressure piston is located above the partitioning guide groove, one end of the air pressure piston is located in the air compression cavity, and the other end of the air pressure piston is located in the rotary chopping cavity. The interior of the rotary chopping cavity is movably connected with a mincing cutter; and an adjusting module. According to the parathyroid gland autoimplantation device, the injector type handheld device is adopted, the human engineering design is met, the switching use design of the rotary chopping cavity and the air compression cavity integrates the two operation requirements, the operation process is simplified, use is convenient and fast, the treatment difficulty is reduced, the error rate is reduced, and the treatment efficiency is improved. And meanwhile, the modular design has the effects of reliability and safety.

The application relates to a parathyroid real-time detection method based on Anchor-Free and space-time consistency. An Anchor-Free base convolutional neural network and a feature pyramid model are used to perform feature extraction on a detection image to generate a pyramid multi-scale feature map group, then a shared detection head is used to obtain a plurality of scale corresponding classification confidence maps, a center confidence map and a target frame regression map, and then the classification confidence map and the center confidence map are multiplied to obtain a center classification confidence map. A space-time classification memory map is constructed, information is extracted by using the center confidence map, a time sequence classification result map is generated, and the time sequence classification result map and the center confidence map are fused to generate a final classification confidence map. The application enhances the detection effect and the adaptability of the detection network, and alleviates the target drift problem of the detector under complex conditions such as shielding, fog and illumination when the parathyroid is encountered.

Methods for treating vitamin D insufficiency and secondary hyperparathyroidism in patients having CKD comprising administering repeat doses of 25-hydroxyvitamin D are disclosed. The methods comprise administering 25-hydroxyvitamin D in an amount effective to safely raise the patient's serum 25-hydroxyvitamin D level to greater than 90 ng / ml and / or to control the patient's serum ratio of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D to less than 20.

The invention is applicable to the technical field of hyperspectral imaging and medical treatment, and provides a parathyroid gland operation detection device and method based on spectral microscopy-risk early warning. An eyepiece group; the imaging spectrometer is used for collecting a hyperspectral image of the to-be-detected tissue; the electric control adjustable light splitting system is used for splitting the optical signal output by the microscopic imaging system to the eyepiece group and the imaging spectrometer and adaptively adjusting the light intensity split to the eyepiece group and the imaging spectrometer; the dye-free near-infrared imaging unit is used for collecting an autofluorescence signal of the tissue to be detected; the parathyroid gland recognition module is used for performing weighted fusion on the hyperspectral image and the autofluorescence signal and recognizing parathyroid gland tissues according to a weighted fusion result; and the operation risk early warning unit is used for identifying the blood vessel based on the hemoglobin characteristic peak in the hyperspectral image and triggering an alarm when the operation instrument approaches the blood vessel. The precision and safety of parathyroid gland surgery can be remarkably improved.

The invention discloses a photosensitizer capable of targeting to parathyroid glands and a preparation method of the photosensitizer. A compound structure of the photosensitizer is shown as a formula I in the specification. The ICG dye is a commercial dye parent, through a series of screening on the ICG dye, targeting on parathyroid glands is expected to be achieved through the inherent targeting characteristics of the structure, meanwhile, modification is conducted on the two sides of the T800 cyanine dye, asymmetric F atoms, I atoms, F atoms and Br atoms are introduced, the existence of the F atoms guarantees the targeting efficiency, and meanwhile the targeting efficiency is improved. The introduction of the heavy atoms provides a photodynamic therapy effect, and precise targeting imaging and treatment of parathyroid glands are realized. In addition, contrast molecules with double F, double I and double Br introduced into symmetrical positions on two sides are synthesized for comparison. Results show that the T800-FI can realize accurate targeting on parathyroid glands, has an optimal photodynamic ablation effect on the parathyroid glands, can be applied to photodynamic therapy of diseases such as parathyroid carcinoma, parathyroid tumor, hyperparathyroidism and parathyroid cyst, and can realize the effect of accurate recognition and positioning therapy.

The present invention relates to the field of organoid culture technology, in particular to a human parathyroid organoid culture medium and a culture method thereof. In view of the problem of low parathyroid organoid culture efficiency in the prior art, the culture medium provided by the present invention significantly improves the growth efficiency and survival rate of organoids and accelerates the maturation of organoids by optimizing the culture medium formula. The culture medium can effectively support and promote the growth of organoids and is suitable for application scenarios such as disease model establishment, drug screening and cell therapy.